Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1230431..1230993 Replicon chromosome
Accession NZ_CP046257
Organism Gordonia sp. 135

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GKZ92_RS05620 Protein ID WP_006360630.1
Coordinates 1230703..1230993 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GKZ92_RS05615 Protein ID WP_035753144.1
Coordinates 1230431..1230706 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKZ92_RS05595 1226011..1227405 - 1395 WP_006360625.1 allantoinase AllB -
GKZ92_RS05600 1227655..1229208 + 1554 WP_035753147.1 NCS1 family nucleobase:cation symporter-1 -
GKZ92_RS05605 1229229..1229951 + 723 WP_035753146.1 Asp/Glu/hydantoin racemase -
GKZ92_RS05610 1230032..1230250 + 219 WP_042375335.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
GKZ92_RS05615 1230431..1230706 + 276 WP_035753144.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GKZ92_RS05620 1230703..1230993 + 291 WP_006360630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GKZ92_RS05625 1231162..1231974 - 813 WP_035753387.1 (S)-ureidoglycine aminohydrolase -
GKZ92_RS05630 1232031..1233305 - 1275 WP_035753142.1 aldolase -
GKZ92_RS05635 1233456..1234217 + 762 WP_035753140.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10875.35 Da        Isoelectric Point: 10.2270

>T143753 WP_006360630.1 NZ_CP046257:1230703-1230993 [Gordonia sp. 135]
MNDAPTDSPAPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAENPHRLSKPLRDDLGGLHSARRGDYRVLLRIDDPNH
TIVVVRIDHRAHAYRT

Download         Length: 291 bp

>T143753 NZ_CP061349:c1573465-1573214 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9750.93 Da        Isoelectric Point: 4.6221

>AT143753 WP_035753144.1 NZ_CP046257:1230431-1230706 [Gordonia sp. 135]
MTTVPLGEAKDKLSALIDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGLRDDVATADAEYAAGHTVSID
DLRAEHGLPPK

Download         Length: 276 bp

>AT143753 NZ_CP061349:c1573224-1573051 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References