Detailed information of TA system TA143749

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4077586..4078339
• Replicon: chromosome
• Accession: NZ_CP046251
• Organism: Leclercia adecarboxylata strain P12375

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: R8WN26
• Locus tag: GLX29_RS19255
• Protein ID: WP_016154457.1
• Coordinates: 4077962..4078339 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: GLX29_RS19250
• Protein ID: WP_162838704.1
• Coordinates: 4077586..4077912 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLX29_RS19190	4072644..4072910	+	267	WP_009652486.1	hypothetical protein	-
GLX29_RS19195	4072923..4073234	+	312	WP_009652410.1	hypothetical protein	-
GLX29_RS19200	4073281..4073751	+	471	WP_009652431.1	hypothetical protein	-
GLX29_RS19205	4073800..4074312	+	513	WP_009652395.1	DUF4234 domain-containing protein	-
GLX29_RS19210	4074395..4074616	+	222	WP_009652443.1	hypothetical protein	-
GLX29_RS19215	4074672..4074905	+	234	WP_009652474.1	DUF905 domain-containing protein	-
GLX29_RS19220	4075009..4075827	+	819	WP_009652424.1	DUF945 domain-containing protein	-
GLX29_RS19225	4075827..4076081	+	255	WP_009652519.1	hypothetical protein	-
GLX29_RS19230	4076110..4076571	+	462	WP_045890390.1	antirestriction protein	-
GLX29_RS19235	4076582..4076800	+	219	WP_009652503.1	hypothetical protein	-
GLX29_RS19240	4076812..4077294	+	483	WP_016154455.1	DNA repair protein RadC	-
GLX29_RS19245	4077308..4077529	+	222	WP_009652392.1	DUF987 domain-containing protein	-
GLX29_RS19250	4077586..4077912	+	327	WP_162838704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
GLX29_RS19255	4077962..4078339	+	378	WP_016154457.1	TA system toxin CbtA family protein	Toxin
GLX29_RS19260	4078336..4078827	+	492	WP_009652438.1	hypothetical protein	-
GLX29_RS19265	4078857..4079060	+	204	WP_009652505.1	DUF957 domain-containing protein	-
GLX29_RS19270	4079141..4079986	+	846	Protein_3759	DUF4942 domain-containing protein	-
GLX29_RS19275	4080445..4081086	-	642	WP_103792623.1	deoxynucleoside kinase	-
GLX29_RS19280	4081334..4081675	-	342	WP_032614074.1	DUF1971 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14168.19 Da
• Isoelectric Point: 9.5224

>T143749 WP_016154457.1 NZ_CP046251:4077962-4078339 [Leclercia adecarboxylata]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T143749 NZ_CP061340:c76090-75692 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGCACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12079.85 Da
• Isoelectric Point: 6.6283

>AT143749 WP_162838704.1 NZ_CP046251:4077586-4077912 [Leclercia adecarboxylata]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Nucleotide

• Length: 327 bp

>AT143749 NZ_CP061340:c76317-76090 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Structures

Toxin

• AlphaFold DB: R8WN26