Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3940562..3941222 Replicon chromosome
Accession NZ_CP046251
Organism Leclercia adecarboxylata strain P12375

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag GLX29_RS18560 Protein ID WP_032613858.1
Coordinates 3940562..3940975 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag GLX29_RS18565 Protein ID WP_032613860.1
Coordinates 3940956..3941222 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLX29_RS18540 3936560..3938293 - 1734 WP_155167270.1 single-stranded-DNA-specific exonuclease RecJ -
GLX29_RS18545 3938299..3939012 - 714 WP_032613852.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GLX29_RS18550 3939038..3939934 - 897 WP_032613854.1 site-specific tyrosine recombinase XerD -
GLX29_RS18555 3940036..3940557 + 522 WP_117386687.1 flavodoxin FldB -
GLX29_RS18560 3940562..3940975 - 414 WP_032613858.1 protein YgfX Toxin
GLX29_RS18565 3940956..3941222 - 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
GLX29_RS18570 3941527..3942507 + 981 WP_155167272.1 tRNA-modifying protein YgfZ -
GLX29_RS18575 3942637..3943296 - 660 WP_032613865.1 hemolysin III family protein -
GLX29_RS18580 3943462..3943773 - 312 WP_032613867.1 N(4)-acetylcytidine aminohydrolase -
GLX29_RS18585 3943826..3944557 + 732 WP_032613869.1 MurR/RpiR family transcriptional regulator -
GLX29_RS18590 3944670..3946103 + 1434 WP_155167274.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T143748 WP_032613858.1 NZ_CP046251:c3940975-3940562 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T143748 NZ_CP061340:45538-45696 [Escherichia coli]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT143748 WP_032613860.1 NZ_CP046251:c3941222-3940956 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT143748 NZ_CP061340:45275-45473 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGATTATTTTCAGGAAGAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References