Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 3627481..3628214 Replicon chromosome
Accession NZ_CP046251
Organism Leclercia adecarboxylata strain P12375

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag GLX29_RS17165 Protein ID WP_155167160.1
Coordinates 3627885..3628214 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GLX29_RS17160 Protein ID WP_060617827.1
Coordinates 3627481..3627846 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLX29_RS17130 3623478..3623783 + 306 WP_155167154.1 hypothetical protein -
GLX29_RS17135 3623827..3624708 + 882 WP_155167155.1 hypothetical protein -
GLX29_RS17140 3625383..3626207 + 825 WP_155167156.1 DUF945 domain-containing protein -
GLX29_RS17145 3626239..3626682 + 444 WP_155167157.1 antirestriction protein -
GLX29_RS17150 3626695..3627237 + 543 WP_155167158.1 DNA repair protein RadC -
GLX29_RS17155 3627234..3627455 + 222 WP_155167159.1 DUF987 domain-containing protein -
GLX29_RS17160 3627481..3627846 + 366 WP_060617827.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GLX29_RS17165 3627885..3628214 + 330 WP_155167160.1 TA system toxin CbtA family protein Toxin
GLX29_RS17170 3628531..3628821 - 291 WP_167540286.1 antibiotic biosynthesis monooxygenase -
GLX29_RS17175 3628838..3629839 - 1002 WP_032613327.1 zinc-binding alcohol dehydrogenase family protein -
GLX29_RS17180 3629948..3630850 + 903 WP_059307360.1 LysR family transcriptional regulator -
GLX29_RS17185 3630921..3631775 + 855 WP_059309077.1 kinase -
GLX29_RS17190 3631819..3632283 - 465 WP_155167161.1 YhcH/YjgK/YiaL family protein -
GLX29_RS17195 3632280..3633155 - 876 WP_155167162.1 N-acetylmannosamine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3612995..3628836 15841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12378.18 Da        Isoelectric Point: 7.2414

>T143747 WP_155167160.1 NZ_CP046251:3627885-3628214 [Leclercia adecarboxylata]
MQTLSSYPTRAAQPCLSPIEIWQCLLPHLLSQHYGLTLNDTPFSNETTIQEHIDAGISLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKTNMK

Download         Length: 330 bp

>T143747 NZ_CP061340:26131-26436 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCTTGCTGTCAGATAAAGTCTCCCGTGAACTTTATCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCTGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13498.22 Da        Isoelectric Point: 6.4731

>AT143747 WP_060617827.1 NZ_CP046251:3627481-3627846 [Leclercia adecarboxylata]
MNNHSESGTKPDNPACQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGAFSDGDVLHLDQAFPLILKQLELMLTSGK
LNPRYQHCVTFYHNGLTCEADTLGSCGYIYIAIYPDQTEPH

Download         Length: 366 bp

>AT143747 NZ_CP061340:25911-26129 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCCAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References