Detailed information of TA system TA143737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2265900..2267465
• Replicon: chromosome
• Accession: NZ_CP046251
• Organism: Leclercia adecarboxylata strain P12375

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GLX29_RS10690
• Protein ID: WP_155166769.1
• Coordinates: 2265900..2267210 (-)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GLX29_RS10695
• Protein ID: WP_032618098.1
• Coordinates: 2267214..2267465 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLX29_RS10675	2261381..2262562	-	1182	WP_032618094.1	PLP-dependent aminotransferase family protein	-
GLX29_RS10680	2262695..2264692	-	1998	WP_103792383.1	TonB-dependent receptor	-
GLX29_RS10685	2264703..2265764	-	1062	WP_155166768.1	YncE family protein	-
GLX29_RS10690	2265900..2267210	-	1311	WP_155166769.1	type II toxin-antitoxin system HipA family toxin	Toxin
GLX29_RS10695	2267214..2267465	-	252	WP_032618098.1	helix-turn-helix domain-containing protein	Antitoxin
GLX29_RS10700	2267682..2267948	-	267	WP_155166770.1	hypothetical protein	-
GLX29_RS10705	2268264..2272064	+	3801	WP_155166771.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 48196.35 Da
• Isoelectric Point: 6.5047

>T143737 WP_155166769.1 NZ_CP046251:c2267210-2265900 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLEGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLYDVISAFPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEAARRLLAEMAERTDDV
IASVRAELPPDFPAQVSEAIFKGLASQAARIGRFVS

Nucleotide

• Length: 1311 bp

>T143737 NZ_CP061339:c1957937-1957830 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9223.56 Da
• Isoelectric Point: 10.1945

>AT143737 WP_032618098.1 NZ_CP046251:c2267465-2267214 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Nucleotide

• Length: 252 bp

>AT143737 NZ_CP061339:1957990-1958051 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT