143736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1071874..1072493 Replicon chromosome
Accession NZ_CP046251
Organism Leclercia adecarboxylata strain P12375

Toxin (Protein)


Gene name Hha Uniprot ID A0A345CDT0
Locus tag GLX29_RS05000 Protein ID WP_032616864.1
Coordinates 1071874..1072092 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3E1ZZ82
Locus tag GLX29_RS05005 Protein ID WP_032616865.1
Coordinates 1072101..1072493 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLX29_RS04980 1068718..1069071 + 354 WP_032616860.1 DUF1428 family protein -
GLX29_RS04985 1069104..1070672 - 1569 WP_032616861.1 EAL domain-containing protein -
GLX29_RS04990 1070938..1071078 + 141 WP_032616862.1 type B 50S ribosomal protein L36 -
GLX29_RS04995 1071138..1071602 - 465 WP_032616863.1 membrane protein -
GLX29_RS05000 1071874..1072092 - 219 WP_032616864.1 hemolysin expression modulator Hha Toxin
GLX29_RS05005 1072101..1072493 - 393 WP_032616865.1 Hha toxicity modulator TomB Antitoxin
GLX29_RS05010 1072985..1076125 - 3141 WP_059308599.1 multidrug efflux RND transporter permease subunit AcrB -
GLX29_RS05015 1076148..1077341 - 1194 WP_032616867.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1061608..1072493 10885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T143736 WP_032616864.1 NZ_CP046251:c1072092-1071874 [Leclercia adecarboxylata]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T143736 NZ_CP061339:c1957402-1957295 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15093.98 Da        Isoelectric Point: 4.8941

>AT143736 WP_032616865.1 NZ_CP046251:c1072493-1072101 [Leclercia adecarboxylata]
MDEYSPKRQDIAQLKFLCESLYHDCLSNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASKANPLASPVKIITNN

Download         Length: 393 bp

>AT143736 NZ_CP061339:1957450-1957516 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345CDT0

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1ZZ82

References