Detailed information of TA system TA143735

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 912392..913050
• Replicon: chromosome
• Accession: NZ_CP046251
• Organism: Leclercia adecarboxylata strain P12375

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: GLX29_RS04205
• Protein ID: WP_032637385.1
• Coordinates: 912392..912712 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: GLX29_RS04210
• Protein ID: WP_032637384.1
• Coordinates: 912733..913050 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLX29_RS04185	907443..908981	+	1539	WP_032637388.1	sugar ABC transporter ATP-binding protein	-
GLX29_RS04190	909077..910066	+	990	WP_072320433.1	ABC transporter permease	-
GLX29_RS04195	910155..911105	+	951	WP_048232733.1	D-ribose ABC transporter substrate-binding protein	-
GLX29_RS04200	911236..912093	+	858	WP_001581455.1	DeoR/GlpR family DNA-binding transcription regulator	-
GLX29_RS04205	912392..912712	-	321	WP_032637385.1	TA system toxin CbtA family protein	Toxin
GLX29_RS04210	912733..913050	-	318	WP_032637384.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
GLX29_RS04215	913069..913290	-	222	WP_032637383.1	DUF987 domain-containing protein	-
GLX29_RS04220	913299..913775	-	477	WP_000811693.1	RadC family protein	-
GLX29_RS04225	913791..914249	-	459	WP_000211838.1	antirestriction protein	-
GLX29_RS04230	914347..914586	-	240	WP_000194654.1	DUF905 domain-containing protein	-
GLX29_RS04235	914663..915130	-	468	WP_001547765.1	hypothetical protein	-
GLX29_RS04240	915153..915596	-	444	WP_001547764.1	phage transcriptional regulator	-
GLX29_RS04245	915596..915832	-	237	WP_001144031.1	hypothetical protein	-
GLX29_RS04250	915873..916574	-	702	WP_001581462.1	WYL domain-containing protein	-
GLX29_RS04255	916791..917612	-	822	WP_155166353.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-104)

Antitoxin

• Antitoxin CbeA (5-103)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12146.14 Da
• Isoelectric Point: 7.1656

>T143735 WP_032637385.1 NZ_CP046251:c912712-912392 [Leclercia adecarboxylata]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPFITAVDILKARRAMREMRT

Nucleotide

• Length: 321 bp

>T143735 NZ_CP061339:c1836016-1835522 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12020.58 Da
• Isoelectric Point: 6.7389

>AT143735 WP_032637384.1 NZ_CP046251:c913050-912733 [Leclercia adecarboxylata]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYVYITVYPTHR

Nucleotide

• Length: 318 bp

>AT143735 NZ_CP061339:c1836306-1836013 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA