143719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1015581..1016080 Replicon chromosome
Accession NZ_CP046246
Organism Tetragenococcus halophilus strain YJ1

Toxin (Protein)


Gene name relE Uniprot ID A0A2H6CIH1
Locus tag GLW17_RS04750 Protein ID WP_028790514.1
Coordinates 1015581..1015850 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2H6CIE0
Locus tag GLW17_RS04755 Protein ID WP_028790515.1
Coordinates 1015847..1016080 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLW17_RS04715 1011154..1011420 - 267 WP_155224378.1 PRD domain-containing protein -
GLW17_RS04720 1011455..1012009 - 555 WP_155224379.1 PRD domain-containing protein -
GLW17_RS04725 1012414..1012647 - 234 WP_103097398.1 toxin-antitoxin system, antitoxin component -
GLW17_RS04730 1012741..1013685 - 945 WP_103097396.1 acetamidase/formamidase family protein -
GLW17_RS04735 1013815..1014006 + 192 WP_014123808.1 type II toxin-antitoxin system HicA family toxin -
GLW17_RS04740 1014045..1014446 + 402 WP_014123807.1 type II toxin-antitoxin system HicB family antitoxin -
GLW17_RS04745 1014869..1015147 - 279 WP_155224380.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GLW17_RS04750 1015581..1015850 - 270 WP_028790514.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GLW17_RS04755 1015847..1016080 - 234 WP_028790515.1 toxin-antitoxin system antitoxin component Antitoxin
GLW17_RS04760 1016267..1017217 - 951 WP_155224381.1 acetamidase/formamidase family protein -
GLW17_RS04765 1017646..1018782 - 1137 WP_155224382.1 hypothetical protein -
GLW17_RS04770 1018882..1020240 - 1359 WP_014123593.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10466.29 Da        Isoelectric Point: 10.7843

>T143719 WP_028790514.1 NZ_CP046246:c1015850-1015581 [Tetragenococcus halophilus]
MTFHVETTPRFDKQLKKLDKFAAKTILKWLDKNIEGSNNPRLMGKPLVGNHSGKWRYRIGSYRVITKVDDEKLIILALEV
GHRKDIYRK

Download         Length: 270 bp

>T143719 NZ_CP061337:c2545481-2545378 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8580.36 Da        Isoelectric Point: 3.8595

>AT143719 WP_028790515.1 NZ_CP046246:c1016080-1015847 [Tetragenococcus halophilus]
MATITVRVTDEEKDFLDNMAKFEGKSLSELLKTTTLSSLEDAYDAQIGDAAYDEYLKNPQSHPLSESLEEYGLGESE

Download         Length: 234 bp

>AT143719 NZ_CP061337:2545340-2545611 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6CIH1

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CIE0

References