Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 937084..937577 Replicon chromosome
Accession NZ_CP046246
Organism Tetragenococcus halophilus strain YJ1

Toxin (Protein)


Gene name relE Uniprot ID A0A2H6C3W3
Locus tag GLW17_RS04355 Protein ID WP_014123900.1
Coordinates 937084..937350 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2H6CKH8
Locus tag GLW17_RS04360 Protein ID WP_014123899.1
Coordinates 937347..937577 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLW17_RS04330 933530..933775 - 246 WP_061840030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GLW17_RS04335 933951..934655 + 705 WP_069028717.1 DUF969 domain-containing protein -
GLW17_RS04340 934639..935559 + 921 WP_069028716.1 DUF979 domain-containing protein -
GLW17_RS04345 935886..936533 + 648 WP_014123904.1 pyroglutamyl-peptidase I -
GLW17_RS04350 936689..936871 + 183 WP_014123901.1 putative holin-like toxin -
GLW17_RS04355 937084..937350 - 267 WP_014123900.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GLW17_RS04360 937347..937577 - 231 WP_014123899.1 hypothetical protein Antitoxin
GLW17_RS04365 937744..937980 + 237 WP_014123898.1 hypothetical protein -
GLW17_RS04370 938297..939658 + 1362 Protein_864 transposase -
GLW17_RS04375 940234..941466 + 1233 WP_061840037.1 mechanosensitive ion channel -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10597.17 Da        Isoelectric Point: 10.0661

>T143717 WP_014123900.1 NZ_CP046246:c937350-937084 [Tetragenococcus halophilus]
MSYRLVFTSEIQKQFRKMDKYQATLITRWLYQHIDGIDDPRKFGKELTTNRSGQWRYRIGKYRVIVEIEDSQLVVLAVQV
GHEKNVYN

Download         Length: 267 bp

>T143717 NZ_CP061337:c2184701-2184423 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.94 Da        Isoelectric Point: 3.9487

>AT143717 WP_014123899.1 NZ_CP046246:c937577-937347 [Tetragenococcus halophilus]
MAMITVRVSDAEKEWLNYMADFYGISLSDLLKTYSMEQLEDEYDRQTAEIAYKHWLENGKQTVSMDEILSEFGGLE

Download         Length: 231 bp

>AT143717 NZ_CP061337:c2184423-2184139 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6C3W3

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CKH8

References