Detailed information of TA system TA143716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 1060810..1061438
• Replicon: chromosome
• Accession: NZ_CP046242
• Organism: Bizionia sp. M204

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GMA17_RS04750
• Protein ID: WP_248399664.1
• Coordinates: 1060810..1061055 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GMA17_RS04755
• Protein ID: WP_248399666.1
• Coordinates: 1061058..1061438 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GMA17_RS04745 (GMA17_04730)	1057224..1060127	+	2904	WP_248399662.1	NACHT domain-containing protein	-
GMA17_RS04750 (GMA17_04735)	1060810..1061055	+	246	WP_248399664.1	type II toxin-antitoxin system HicA family toxin	Toxin
GMA17_RS04755 (GMA17_04740)	1061058..1061438	+	381	WP_248399666.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GMA17_RS04760 (GMA17_04745)	1061988..1063037	-	1050	WP_248399668.1	NAD(P)-dependent alcohol dehydrogenase	-
GMA17_RS04765 (GMA17_04750)	1063124..1064224	-	1101	WP_248399670.1	alkene reductase	-
GMA17_RS04770 (GMA17_04755)	1064543..1065853	-	1311	WP_248399672.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9449.16 Da
• Isoelectric Point: 10.5616

>T143716 WP_248399664.1 NZ_CP046242:1060810-1061055 [Bizionia sp. M204]
VAKIDKLILKIQANPKDFTWDELKKVLSHFGYEEMPQKGKTGGSRRKFVNNKKEVISLHEPHPKKIVKSYVIKQIIEHLN
L

Nucleotide

• Length: 246 bp

>T143716 NZ_CP061337:2135222-2135398 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14384.27 Da
• Isoelectric Point: 4.9680

>AT143716 WP_248399666.1 NZ_CP046242:1061058-1061438 [Bizionia sp. M204]
MSDYLTYKGYFGTVNFNSDDEVFYGKIFGISDLINFEGSSVKELKESFEESLDDYLETCKALNKTPDKTFKGSFNVRVSM
ELHKKAAMIANQKSISLNDFVKKAIDYAVSHDKDLDEITTMKTQKM

Nucleotide

• Length: 381 bp

>AT143716 NZ_CP061337:2135444-2135860 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA