Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 818474..819061 Replicon chromosome
Accession NZ_CP046242
Organism Bizionia sp. M204

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GMA17_RS03655 Protein ID WP_248399242.1
Coordinates 818474..818773 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GMA17_RS03660 Protein ID WP_248399244.1
Coordinates 818777..819061 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMA17_RS03630 (GMA17_03620) 813852..814754 + 903 WP_248399234.1 ATP-grasp domain-containing protein -
GMA17_RS03635 (GMA17_03625) 814891..815754 - 864 WP_248399236.1 helix-turn-helix domain-containing protein -
GMA17_RS03640 815831..816550 - 720 WP_248399238.1 hypothetical protein -
GMA17_RS03645 (GMA17_03635) 816884..817516 + 633 WP_248399240.1 hypothetical protein -
GMA17_RS03650 (GMA17_03640) 817675..818241 + 567 WP_248395786.1 hypothetical protein -
GMA17_RS03655 (GMA17_03645) 818474..818773 + 300 WP_248399242.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GMA17_RS03660 (GMA17_03650) 818777..819061 + 285 WP_248399244.1 putative addiction module antidote protein Antitoxin
GMA17_RS03665 (GMA17_03655) 819223..819855 + 633 WP_248399246.1 hypothetical protein -
GMA17_RS03670 (GMA17_03660) 820053..820694 - 642 WP_248399248.1 DUF6266 family protein -
GMA17_RS03675 (GMA17_03665) 820808..821272 - 465 WP_248399251.1 hypothetical protein -
GMA17_RS03680 (GMA17_03670) 821522..821689 - 168 WP_248399253.1 hypothetical protein -
GMA17_RS03685 (GMA17_03675) 822504..823058 - 555 WP_248399255.1 hypothetical protein -
GMA17_RS03690 (GMA17_03680) 823039..823362 - 324 WP_248399257.1 STAS-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-93)

Antitoxin

Uncharacterized protein HI1420

(8-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11717.84 Da        Isoelectric Point: 10.4596

>T143715 WP_248399242.1 NZ_CP046242:818474-818773 [Bizionia sp. M204]
MFFIEKTNEFDKWLKKLKDFKAKAKILFRIQKLETDEHFGDCKTVGDGIREMRINFAKGYRVYFKEKDGKVIVLLIGGDK
STQQKDIAKAKEIWKKLNK

Download         Length: 300 bp

>T143715 NZ_CP061337:c1957698-1957591 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10100.67 Da        Isoelectric Point: 5.0508

>AT143715 WP_248399244.1 NZ_CP046242:818777-819061 [Bizionia sp. M204]
MGTSRFEIADYLESKEMIAEYLNTVLEEGNNADIINAIGHIAKAIGMTKIAEETGLSRPSLYKALSDGAKPQFATIMKVL
KAIGGQIQVNPMSA

Download         Length: 285 bp

>AT143715 NZ_CP061337:1957751-1957812 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References