Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 9057454..9057995 Replicon chromosome
Accession NZ_CP046172
Organism Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F5544_RS41015 Protein ID WP_167478123.1
Coordinates 9057454..9057789 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F5544_RS41020 Protein ID WP_203217719.1
Coordinates 9057786..9057995 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5544_RS40995 9052839..9054935 - 2097 WP_167478119.1 elongation factor G -
F5544_RS41000 9055194..9056384 - 1191 WP_167478120.1 elongation factor Tu -
F5544_RS41005 9056490..9056876 - 387 WP_167478121.1 hypothetical protein -
F5544_RS41010 9056873..9057355 - 483 WP_167478122.1 hypothetical protein -
F5544_RS41015 9057454..9057789 - 336 WP_167478123.1 DUF5615 family PIN-like protein Toxin
F5544_RS41020 9057786..9057995 - 210 WP_203217719.1 DUF433 domain-containing protein Antitoxin
F5544_RS41025 9058101..9059291 - 1191 WP_167478125.1 elongation factor Tu -
F5544_RS41030 9059408..9061510 - 2103 WP_167478126.1 elongation factor G -
F5544_RS41035 9061661..9062131 - 471 WP_167478127.1 30S ribosomal protein S7 -
F5544_RS41040 9062133..9062507 - 375 WP_014353064.1 30S ribosomal protein S12 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-79)

Antitoxin

Protein of unknown function DUF433

(1-56)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12199.11 Da        Isoelectric Point: 5.1041

>T143713 WP_167478123.1 NZ_CP046172:c9057789-9057454 [Nocardia arthritidis]
MRFLVDAQLPPALARALADHGHDAVHVCDIDLTSAPDHQVWQEALRRDAVIVTKDEDFILIGKGRSGEPGPAVVWIRIGN
CTRRALLDAFLPVLPTVVEMLQAGETIVEIR

Download         Length: 336 bp

>T143713 NZ_CP061337:c1835777-1835283 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7719.81 Da        Isoelectric Point: 4.3854

>AT143713 WP_203217719.1 NZ_CP046172:c9057995-9057786 [Nocardia arthritidis]
ITFDPNQCGGRPCIRGMRIRVKDVLELLAAGETEDSILADYPYLEREDIRACLEFAAAEIDHPILRTAS

Download         Length: 210 bp

>AT143713 NZ_CP061337:c1836067-1835774 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References