Detailed information of TA system TA143713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 9057454..9057995
• Replicon: chromosome
• Accession: NZ_CP046172
• Organism: Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F5544_RS41015
• Protein ID: WP_167478123.1
• Coordinates: 9057454..9057789 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: F5544_RS41020
• Protein ID: WP_203217719.1
• Coordinates: 9057786..9057995 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F5544_RS40995	9052839..9054935	-	2097	WP_167478119.1	elongation factor G	-
F5544_RS41000	9055194..9056384	-	1191	WP_167478120.1	elongation factor Tu	-
F5544_RS41005	9056490..9056876	-	387	WP_167478121.1	hypothetical protein	-
F5544_RS41010	9056873..9057355	-	483	WP_167478122.1	hypothetical protein	-
F5544_RS41015	9057454..9057789	-	336	WP_167478123.1	DUF5615 family PIN-like protein	Toxin
F5544_RS41020	9057786..9057995	-	210	WP_203217719.1	DUF433 domain-containing protein	Antitoxin
F5544_RS41025	9058101..9059291	-	1191	WP_167478125.1	elongation factor Tu	-
F5544_RS41030	9059408..9061510	-	2103	WP_167478126.1	elongation factor G	-
F5544_RS41035	9061661..9062131	-	471	WP_167478127.1	30S ribosomal protein S7	-
F5544_RS41040	9062133..9062507	-	375	WP_014353064.1	30S ribosomal protein S12	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-79)

Antitoxin

• Protein of unknown function DUF433 (1-56)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12199.11 Da
• Isoelectric Point: 5.1041

>T143713 WP_167478123.1 NZ_CP046172:c9057789-9057454 [Nocardia arthritidis]
MRFLVDAQLPPALARALADHGHDAVHVCDIDLTSAPDHQVWQEALRRDAVIVTKDEDFILIGKGRSGEPGPAVVWIRIGN
CTRRALLDAFLPVLPTVVEMLQAGETIVEIR

Nucleotide

• Length: 336 bp

>T143713 NZ_CP061337:c1835777-1835283 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7719.81 Da
• Isoelectric Point: 4.3854

>AT143713 WP_203217719.1 NZ_CP046172:c9057995-9057786 [Nocardia arthritidis]
ITFDPNQCGGRPCIRGMRIRVKDVLELLAAGETEDSILADYPYLEREDIRACLEFAAAEIDHPILRTAS

Nucleotide

• Length: 210 bp

>AT143713 NZ_CP061337:c1836067-1835774 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA