Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 8478582..8479216 Replicon chromosome
Accession NZ_CP046172
Organism Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F5544_RS38365 Protein ID WP_167477685.1
Coordinates 8478797..8479216 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F5544_RS38360 Protein ID WP_167477684.1
Coordinates 8478582..8478800 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5544_RS38335 8474214..8474834 + 621 WP_167477681.1 hypothetical protein -
F5544_RS38340 8474797..8475711 - 915 WP_167477682.1 DMT family transporter -
F5544_RS38345 8475775..8476602 + 828 WP_203217440.1 AraC family transcriptional regulator -
F5544_RS38350 8476685..8477245 - 561 WP_167477683.1 TetR/AcrR family transcriptional regulator -
F5544_RS38355 8477404..8478513 + 1110 WP_167479776.1 cytochrome P450 -
F5544_RS38360 8478582..8478800 + 219 WP_167477684.1 ribbon-helix-helix protein, CopG family Antitoxin
F5544_RS38365 8478797..8479216 + 420 WP_167477685.1 PIN domain nuclease Toxin
F5544_RS38370 8479206..8480213 + 1008 WP_167479777.1 hypothetical protein -
F5544_RS38375 8480220..8481170 - 951 WP_167477686.1 DMT family transporter -
F5544_RS38380 8481143..8482195 - 1053 WP_167477687.1 iron-containing redox enzyme family protein -
F5544_RS38385 8482182..8483213 - 1032 WP_167477688.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-36)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15475.83 Da        Isoelectric Point: 5.0045

>T143712 WP_167477685.1 NZ_CP046172:8478797-8479216 [Nocardia arthritidis]
MTARPWLIDKSALVRLGQSPDAEEWAERIERGLVRIATVTLLEAGYSARSATDLTELLDLPPLARMPVEYMTPTAEDRAV
DVLRILAERGHHRAPSIPDLLIAATAEQAKLVVLHADKDFELIAGVTGQPVEWLRFDKR

Download         Length: 420 bp

>T143712 NZ_CP061337:c1519606-1519220 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8197.40 Da        Isoelectric Point: 6.2886

>AT143712 WP_167477684.1 NZ_CP046172:8478582-8478800 [Nocardia arthritidis]
MTDILIRDIPDSTIEEIDRRAKGMGVSRTEFLRRWLSRDFRPAVPVTARDLGRLGALVQDLDNPDVMGKAWS

Download         Length: 219 bp

>AT143712 NZ_CP061337:c1519230-1518901 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References