Detailed information of TA system TA143710

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 7250706..7251436
• Replicon: chromosome
• Accession: NZ_CP046172
• Organism: Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F5544_RS32490
• Protein ID: WP_167476716.1
• Coordinates: 7250706..7251134 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: F5544_RS32495
• Protein ID: WP_167479621.1
• Coordinates: 7251131..7251436 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F5544_RS32465	7246805..7247491	-	687	WP_167476712.1	response regulator transcription factor	-
F5544_RS32470	7247680..7248132	-	453	WP_167476713.1	flavodoxin family protein	-
F5544_RS32475	7248157..7249230	-	1074	WP_167476714.1	NADAR family protein	-
F5544_RS32480	7249311..7249808	-	498	WP_167476715.1	hypothetical protein	-
F5544_RS32485	7249805..7250550	-	746	Protein_6412	4-hydroxy-tetrahydrodipicolinate reductase	-
F5544_RS32490	7250706..7251134	-	429	WP_167476716.1	type II toxin-antitoxin system VapC family toxin	Toxin
F5544_RS32495	7251131..7251436	-	306	WP_167479621.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F5544_RS32500	7251505..7251909	-	405	WP_167476717.1	MarR family transcriptional regulator	-
F5544_RS32505	7251971..7252426	+	456	WP_167476718.1	MarR family winged helix-turn-helix transcriptional regulator	-
F5544_RS32510	7252405..7253511	-	1107	WP_167476719.1	alcohol dehydrogenase catalytic domain-containing protein	-
F5544_RS32515	7253678..7254073	+	396	WP_167479622.1	VOC family protein	-
F5544_RS32520	7254110..7255504	-	1395	WP_167479623.1	pentapeptide repeat-containing protein	-
F5544_RS32525	7255604..7256161	-	558	WP_203217399.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (17-78)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 16207.64 Da
• Isoelectric Point: 8.5255

>T143710 WP_167476716.1 NZ_CP046172:c7251134-7250706 [Nocardia arthritidis]
VKNYLLDTCTVSEWTKPRPNRGLIRWLHLADEDRLHLSVISLGEIRKGIEMLPDSAKKQRLVDWLTDSLTVRFRDRILPV
DAVVAQAWGRMVARTERNRDRMDAADALIAATAESYGLEVVTRNVKHFGPTGVRVLCPWSDE

Nucleotide

• Length: 429 bp

>T143710 NZ_CP061337:c588641-588432 [Escherichia coli]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11574.01 Da
• Isoelectric Point: 4.5740

>AT143710 WP_167479621.1 NZ_CP046172:c7251436-7251131 [Nocardia arthritidis]
MARKRNDSEQRVEIDIAWPLAEAKARFSELIDRVEREGPQVISKHGREVAVVVPVDEWRQKSAREGSFAEFLASSPLRGV
DIEITRIELDPREVDFSDVEL

Nucleotide

• Length: 306 bp

>AT143710 NZ_CP061337:588633-588690 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA