143708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 618133..618698 Replicon chromosome
Accession NZ_CP046172
Organism Nocardia arthritidis strain AUSMDU00012717

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag F5544_RS02915 Protein ID WP_167471730.1
Coordinates 618330..618698 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag F5544_RS02910 Protein ID WP_167471729.1
Coordinates 618133..618330 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5544_RS02885 613155..613574 + 420 WP_167471724.1 glyoxalase/bleomycin resistance/extradiol dioxygenase family protein -
F5544_RS02890 613686..614468 - 783 WP_167471725.1 crotonase/enoyl-CoA hydratase family protein -
F5544_RS02895 614528..616177 + 1650 WP_167471726.1 acyl-CoA synthetase -
F5544_RS02900 616197..617387 - 1191 WP_167471727.1 FAD-dependent monooxygenase -
F5544_RS02905 617485..618063 + 579 WP_167471728.1 TetR family transcriptional regulator -
F5544_RS02910 618133..618330 + 198 WP_167471729.1 hypothetical protein Antitoxin
F5544_RS02915 618330..618698 + 369 WP_167471730.1 Fic family protein Toxin
F5544_RS02920 618965..620065 - 1101 WP_167471731.1 acyl-CoA/acyl-ACP dehydrogenase -
F5544_RS02925 620088..621281 - 1194 WP_167471732.1 acyl-CoA dehydrogenase family protein -
F5544_RS02930 621432..621620 + 189 WP_167471733.1 ferredoxin -
F5544_RS02935 621664..622569 + 906 WP_174867254.1 3-oxoacyl-ACP reductase -
F5544_RS02940 622853..623617 + 765 WP_167471734.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(20-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13720.53 Da        Isoelectric Point: 4.6754

>T143708 WP_167471730.1 NZ_CP046172:618330-618698 [Nocardia arthritidis]
MQYLTLPELLKLAERLGTPDVRDYGLLESALARPQASVFGQDAYSDVWQKAAALMDSLARNHGLIDDNKRLAWYATWVFL
HMNGHPLDAEFDVDDAEAFVLDVCQGRLEVSQIAGHLSKFTR

Download         Length: 369 bp

>T143708 NZ_CP061337:374664-375014 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7401.33 Da        Isoelectric Point: 6.2170

>AT143708 WP_167471729.1 NZ_CP046172:618133-618330 [Nocardia arthritidis]
MAGLNVRFTDEELGALRQRAEAEGRSMQQFVHDAVIKAINEHARLFNEAADHVLRVSEELNRRLA

Download         Length: 198 bp

>AT143708 NZ_CP061337:374419-374670 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATTTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References