Detailed information of TA system TA143706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 7378047..7378519
• Replicon: chromosome
• Accession: NZ_CP046171
• Organism: Nocardia brasiliensis strain AUSMDU00024985

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F5X71_RS33755
• Protein ID: WP_167465614.1
• Coordinates: 7378316..7378519 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: F5X71_RS33750
• Protein ID: WP_167465613.1
• Coordinates: 7378047..7378319 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F5X71_RS33725	7374805..7375188	+	384	WP_167465609.1	Na(+)/H(+) antiporter subunit C	-
F5X71_RS33730	7375185..7376801	+	1617	WP_167465610.1	Na+/H+ antiporter subunit D	-
F5X71_RS33735	7376825..7377367	+	543	WP_167466949.1	Na+/H+ antiporter subunit E	-
F5X71_RS33740	7377364..7377624	+	261	WP_167465611.1	cation:proton antiporter	-
F5X71_RS33745	7377656..7377991	+	336	WP_167465612.1	monovalent cation/H(+) antiporter subunit G	-
F5X71_RS33750	7378047..7378319	+	273	WP_167465613.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
F5X71_RS33755	7378316..7378519	+	204	WP_167465614.1	Txe/YoeB family addiction module toxin	Toxin
F5X71_RS33760	7378592..7379887	-	1296	WP_167465615.1	phosphatase PAP2 family protein	-
F5X71_RS33765	7380018..7381163	-	1146	WP_167465616.1	glutamate--cysteine ligase	-
F5X71_RS33770	7381177..7381863	-	687	WP_167465617.1	superoxide dismutase family protein	-
F5X71_RS33775	7381994..7382578	-	585	WP_167465618.1	LytR C-terminal domain-containing protein	-
F5X71_RS33780	7382598..7382942	-	345	WP_014988735.1	DUF3263 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	7377656..7388346	10690

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-67)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7882.97 Da
• Isoelectric Point: 9.7793

>T143706 WP_167465614.1 NZ_CP046171:7378316-7378519 [Nocardia brasiliensis]
VKILFTPDAWADYLWWQAHDRATFKRVNKLIDDITPNGYEGIGKPEALRQNLAGFWSRRITSEHRIV

Nucleotide

• Length: 204 bp

>T143706 NZ_CP061335:c5186149-5185922 [Pseudomonas asiatica]
ATGCGCAGTCGCGAAGTTATCCAGCTTATTGAAGCCGACGGCTGGTACCAGGTTGATGTGAAAGGAAGTCATTACCAGTT
CAGGCACCCGACAAAAAGGGGGCGAGTCACGGTTCCTCATCCCAAGAGTGAGCTCCCCAAGGGCACAGTACGCAGCATCT
TGAAGCAGGCTGGCTTGATTCAAGCCAACGGCACTGCCAGCACGAGCATCAACGGAGGTAGTCAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9790.90 Da
• Isoelectric Point: 4.2492

>AT143706 WP_167465613.1 NZ_CP046171:7378047-7378319 [Nocardia brasiliensis]
MRPISITEARANLAAVLDSATEDLEEVVITRAGHEPAVVISLREYESLKETAYLLGNPANARHLERSIAQLRAGEAAPHD
LIEVDDEDTA

Nucleotide

• Length: 273 bp

>AT143706 NZ_CP061335:c5185925-5185518 [Pseudomonas asiatica]
ATGAAATTTCCGGTCGTATTGCACAAAGACGCCGACTCGGACTACGGCGTGACCGTACCTGATGTGCCCGGTTGCTTCAG
CGCCGGTGCCACTGTTGCAAAAGCACTGGAGAATGTTCAGGAAGCGCTGGCACTACATTTTGAAGGGTTGGTCGCAGATA
ACGAGGCATTGCCGCAGGCACAGGAAGTCGACGTCCATGTGGCGAACCCTGACTATGAAGGCGGGGTCTGGGCCGTTGTG
GATTTTGATGTCATCCCGTACCTGGGCAAGGCGGTTCGCTTCAATGCAACGCTGCCGGAAAACCTGCTTCAACGAATCGA
CGAAAAAGTGAAGCGTGATCATCGCTATGCGTCCCGCTCCGGTTTTCTGGCTTCGGCTGCACTGCGAGAGTTGGCCCTTT
CGCACTAA