Detailed information of TA system TA143698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 365140..365638
• Replicon: plasmid pTHAF191c_c
• Accession: NZ_CP046164
• Organism: Vibrio sp. THAF191c

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GGC03_RS26395
• Protein ID: WP_152472926.1
• Coordinates: 365459..365638 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GGC03_RS26390
• Protein ID: WP_152472736.1
• Coordinates: 365140..365364 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GGC03_RS26370	360151..360831	-	681	WP_152472927.1	hypothetical protein	-
GGC03_RS26375	361599..363044	+	1446	WP_154351837.1	hypothetical protein	-
GGC03_RS26380	363055..363762	+	708	WP_152472740.1	OmpA family protein	-
GGC03_RS26385	363807..364886	+	1080	WP_152472738.1	HNH endonuclease	-
GGC03_RS26390	365140..365364	+	225	WP_152472736.1	damage-inducible protein J	Antitoxin
GGC03_RS26395	365459..365638	+	180	WP_152472926.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GGC03_RS26400	365864..366832	-	969	WP_152472734.1	hypothetical protein	-
GGC03_RS26405	366964..367236	-	273	WP_152472733.1	hypothetical protein	-
GGC03_RS26410	367301..369394	-	2094	WP_152472732.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	htpB	1..396310	396310

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-55)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6766.98 Da
• Isoelectric Point: 9.2052

>T143698 WP_152472926.1 NZ_CP046164:365459-365638 [Vibrio sp. THAF191c]
IIEARVENLLEQPHMGVQRDGIRGRLLNTPKISMMVSYCESDTIHIMRVLHQKQKLPAA

Nucleotide

• Length: 180 bp

>T143698 NZ_CP061329:3802187-3802465 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8613.85 Da
• Isoelectric Point: 9.2860

>AT143698 WP_152472736.1 NZ_CP046164:365140-365364 [Vibrio sp. THAF191c]
MDTRIPFGIDDETKRLAQQLADQKRKALFHDARLTEQVNLAFEKFDSKKVTFVDHESAKSCMAERKAKICNRDK

Nucleotide

• Length: 225 bp

>AT143698 NZ_CP061329:3801924-3802184 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA