Detailed information of TA system TA143687

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 299845..300314
• Replicon: chromosome
• Accession: NZ_CP046155
• Organism: Leptolyngbya sp. BL0902

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GFS31_RS01310
• Protein ID: WP_198806525.1
• Coordinates: 300075..300314 (+)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GFS31_RS01305
• Protein ID: WP_198806524.1
• Coordinates: 299845..300078 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFS31_RS01290	295551..296894	+	1344	WP_198806521.1	TldD/PmbA family protein	-
GFS31_RS01295	296991..297218	-	228	WP_198806522.1	hypothetical protein	-
GFS31_RS01300	297501..299396	-	1896	WP_198806523.1	ABC transporter ATP-binding protein/permease	-
GFS31_RS01305	299845..300078	+	234	WP_198806524.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GFS31_RS01310	300075..300314	+	240	WP_198806525.1	type II toxin-antitoxin system VapC family toxin	Toxin
GFS31_RS01315	300330..300479	+	150	WP_198806526.1	hypothetical protein	-
GFS31_RS01320	300716..301009	-	294	WP_198806527.1	hypothetical protein	-
GFS31_RS01325	301159..301803	-	645	WP_198806528.1	hypothetical protein	-
GFS31_RS01330	301929..302144	-	216	WP_198806529.1	hypothetical protein	-
GFS31_RS01335	302512..303516	-	1005	WP_198806530.1	phosphoribulokinase	-
GFS31_RS01340	303915..304691	-	777	WP_198806531.1	enoyl-ACP reductase FabI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-76)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 8980.36 Da
• Isoelectric Point: 6.7130

>T143687 WP_198806525.1 NZ_CP046155:300075-300314 [Leptolyngbya sp. BL0902]
MKYLLDTNICIYIIKHKPPEVRDRFNTHRPLDIGVSAITVAELEYGAYRSQHVEANRAALQQFLLPLEILAFDPAATQA

Nucleotide

• Length: 240 bp

>T143687 NZ_CP061329:1014878-1015213 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8764.88 Da
• Isoelectric Point: 4.0533

>AT143687 WP_198806524.1 NZ_CP046155:299845-300078 [Leptolyngbya sp. BL0902]
METTPLLTNEHGQVVVLPVAFHLNGTEVYIKQVGNAIVLLSTDQPWQPLFDSLSHFTDDFMATREQPPLEDREPLFE

Nucleotide

• Length: 234 bp

>AT143687 NZ_CP061329:1014630-1014878 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA