Detailed information of TA system TA143685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3176198..3176754
• Replicon: chromosome
• Accession: NZ_CP046148
• Organism: Xanthomonas oryzae pv. oryzae strain ITCCBB0002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GKO49_RS15275
• Protein ID: WP_027703932.1
• Coordinates: 3176464..3176754 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: GKO49_RS15270
• Protein ID: WP_011408759.1
• Coordinates: 3176198..3176476 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GKO49_RS15240	3172175..3172642	-	468	WP_027704061.1	energy transducer TonB	-
GKO49_RS15245	3173003..3173662	-	660	WP_012445101.1	energy transducer TonB	-
GKO49_RS15250	3173774..3175123	+	1350	WP_011258822.1	serine--tRNA ligase	-
GKO49_RS15260	3175513..3175713	+	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
GKO49_RS15265	3175685..3176117	+	433	Protein_2913	relaxase	-
GKO49_RS15270	3176198..3176476	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
GKO49_RS15275	3176464..3176754	+	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GKO49_RS15280	3177015..3177212	+	198	WP_153296741.1	hypothetical protein	-
GKO49_RS15285	3177356..3177535	+	180	WP_015463309.1	hypothetical protein	-
GKO49_RS15295	3177870..3178074	+	205	Protein_2918	kfra protein	-
GKO49_RS15305	3178399..3178800	-	402	WP_011259345.1	H-NS histone family protein	-
GKO49_RS15310	3179022..3179198	+	177	Protein_2920	DUF3606 domain-containing protein	-
GKO49_RS22750	3179214..3179420	+	207	Protein_2921	hypothetical protein	-
GKO49_RS15320	3179480..3179796	+	317	Protein_2922	ATP-dependent DNA ligase	-
GKO49_RS15325	3179893..3180984	-	1092	WP_011408756.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T143685 WP_027703932.1 NZ_CP046148:3176464-3176754 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T143685 NZ_CP061329:c604973-604509 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT143685 WP_011408759.1 NZ_CP046148:3176198-3176476 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT143685 NZ_CP061329:c605308-604973 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2