Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 452095..452624 Replicon chromosome
Accession NZ_CP046123
Organism Enterococcus casseliflavus strain EC291

Toxin (Protein)


Gene name relE Uniprot ID A0A7T4GDV7
Locus tag GFU50_RS02140 Protein ID WP_010748738.1
Coordinates 452358..452624 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A377KQM1
Locus tag GFU50_RS02135 Protein ID WP_010748737.1
Coordinates 452095..452358 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFU50_RS02120 447664..448929 - 1266 WP_010748734.1 glycoside hydrolase family 27 protein -
GFU50_RS02125 449050..449949 + 900 WP_010748735.1 AraC family transcriptional regulator -
GFU50_RS02130 450000..451940 + 1941 WP_010748736.1 glycoside hydrolase family 127 protein -
GFU50_RS02135 452095..452358 + 264 WP_010748737.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GFU50_RS02140 452358..452624 + 267 WP_010748738.1 Txe/YoeB family addiction module toxin Toxin
GFU50_RS02145 452817..455648 + 2832 WP_010748739.1 discoidin domain-containing protein -
GFU50_RS02150 455780..456433 - 654 WP_170920125.1 ABC transporter permease -
GFU50_RS02155 456447..457367 - 921 WP_010748740.1 osmoprotectant ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.12 Da        Isoelectric Point: 10.0683

>T143679 WP_010748738.1 NZ_CP046123:452358-452624 [Enterococcus casseliflavus]
MRSDTVTIKNSAKVDLRKIKQSNLKKQFEEVIQALKEDPYMPTQSFEKLRSTHEGRYSRRLNRQHRMVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T143679 NZ_CP061319:c253506-253216 [Polynucleobacter sp. AM-7D1]
TTGAAGACCTATAGTCTTGAGTTCAATGTACTTGCTTTAAAAGAGTGGCAAAAATTAGATAACTCAGTTCGCAGCCAGTT
CAAAAAGCAGCTTGAGAAACGAATTCAAAATCCTAGAGTTGCTTCCGCCAGGTTACATGGTGACCTAGATAATTTCTATA
AGATAAAACTAGCAGCACTTGGCTATAGGCTAGTTTATGAAGTTATAGACCACAGACTTATTGTTCTGATTATTGCAGTT
GGCAAGCGAAATCAGTCAGCTGTTTATAAAAAAGCAGGTAAAAGAAAATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9958.03 Da        Isoelectric Point: 4.2682

>AT143679 WP_010748737.1 NZ_CP046123:452095-452358 [Enterococcus casseliflavus]
MAKTTMNPSTARKNFYQLLKDVNENHTEIEIISDRSGNNAVLIGLGDWRAIQETLFLEQTGTLEKVRDREKDDSGFTDID
DIDWQAL

Download         Length: 264 bp

>AT143679 NZ_CP061319:c253747-253493 [Polynucleobacter sp. AM-7D1]
ATGACAATTACGCAAACCATTCATGCCAAAACTACGGTCAGCATGACTGATCTGAGGCGTAATCCAAGCAAAATTTTAGA
GATTGCAGGGGATCTACCCGTTGCTGTCCTGAATCACAATAAACCTGAAGCCTATCTACTTTCAGCAAAAGCATATGAAG
CGCTGCTTGACTTGGTGGATGACCTCTCACTCATTAAAGTCATTAAAGCGCGCAGCACTGGGAAAACGGTGAAAGTAAAA
CTTGAAGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4GDV7

Antitoxin

Source ID Structure
AlphaFold DB A0A377KQM1

References