Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3876651..3877183 Replicon chromosome
Accession NZ_CP046122
Organism Microlunatus sp. Gsoil 973

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GJV80_RS18220 Protein ID WP_154689111.1
Coordinates 3876651..3876977 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GJV80_RS18225 Protein ID WP_154689112.1
Coordinates 3876974..3877183 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV80_RS18200 3872760..3873428 + 669 Protein_3608 histidine phosphatase family protein -
GJV80_RS18205 3873537..3874118 - 582 WP_154689109.1 phosphotransferase -
GJV80_RS18210 3874891..3876045 + 1155 WP_154689110.1 ATP-binding protein -
GJV80_RS18215 3876214..3876540 + 327 Protein_3611 DUF3024 domain-containing protein -
GJV80_RS18220 3876651..3876977 - 327 WP_154689111.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GJV80_RS18225 3876974..3877183 - 210 WP_154689112.1 antitoxin MazE family protein Antitoxin
GJV80_RS18230 3877641..3878180 - 540 WP_195909007.1 cupin domain-containing protein -
GJV80_RS18235 3878452..3878709 + 258 WP_154689113.1 hypothetical protein -
GJV80_RS18240 3878819..3879211 + 393 WP_154689114.1 hypothetical protein -
GJV80_RS18245 3879211..3879585 + 375 WP_154689115.1 Na+/H+ antiporter NhaA -
GJV80_RS18250 3879742..3879906 - 165 WP_154689116.1 hypothetical protein -
GJV80_RS18255 3880407..3880583 - 177 WP_154689117.1 hypothetical protein -
GJV80_RS18260 3880774..3881784 + 1011 WP_195909008.1 NAD(+)/NADH kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(5-66)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11663.52 Da        Isoelectric Point: 8.7150

>T143678 WP_154689111.1 NZ_CP046122:c3876977-3876651 [Microlunatus sp. Gsoil 973]
VIRGELWTVAGGAYASKPRPALIVQDDVFDATASVTVAPLTSTLTEAPLLRIRIGPSALSGLERDSEIMIDKLTTVRRTN
VANRLGRLTAEQLTEVERAMMAFLGLAR

Download         Length: 327 bp

>T143678 NZ_CP061318:c1308521-1308327 [Polynucleobacter sp. AP-Ainpum-60-G11]
ATGCATAGTAAAAAACTAATTGAGCGACTGAAGGTTGACGGGTGGGTATTAAGCAGAACGAGGGGCTCACACCATATTTT
TACTCACACAACAAAGAGCGGGCATATATGCATCCCGCACCCTAAAAAAGATTTAGGTCTTGGTTTGGTGGAAAAGATAT
TGAAACAGGCTGATATAGAGGGAGGTCTTAAATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8050.86 Da        Isoelectric Point: 4.6028

>AT143678 WP_154689112.1 NZ_CP046122:c3877183-3876974 [Microlunatus sp. Gsoil 973]
MSVKDRVSSYRRRMREQGYRPVQIWVPDVRTERFAAEAHRQAALVAAADRDGDDQDFIEAVSVPWDDEE

Download         Length: 210 bp

>AT143678 NZ_CP061318:c1308330-1307938 [Polynucleobacter sp. AP-Ainpum-60-G11]
ATGAAATATCCGATTGCAATTGAGCCGGGTAATGCCAAGGAGATCTGGGGTGTTGTGGTACCAGATTTAGCAGGGTGCTT
CTCGGCTGGTGATAACAGTATTGATGAAGCAATAGAAAACGCTAAAGAGGCAATAGAGCTTTGGATTGAAGTCGCGCTAG
ATCGAAATCAGGATATCCCAAAGCCAAGCTCTATAAGTGAGCTACAAAAAAAGAAAGAATTTAAAGGATGGGTTTGGGCA
ATCGTGGAGATTGATCCAGCATTGCTCTCGGATGAAATAGAGAGAATTAATATTACCCTACCCAAAAGAGTGCTTGCCAG
GTTGGATGCAAAGGCAAAAAAAGCCGGGGAAAATAGATCAGCATTTATCGCACATTTAGCATTAGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References