Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2812921..2813495 Replicon chromosome
Accession NZ_CP046121
Organism Tetrasphaera sp. HKS02

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GKE56_RS13555 Protein ID WP_154684980.1
Coordinates 2812921..2813250 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GKE56_RS13560 Protein ID WP_154684981.1
Coordinates 2813247..2813495 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKE56_RS13535 2808753..2810843 + 2091 WP_154684977.1 elongation factor G-like protein EF-G2 -
GKE56_RS13540 2810912..2812124 + 1213 Protein_2664 alkane 1-monooxygenase -
GKE56_RS13545 2812121..2812309 + 189 WP_154684978.1 rubredoxin -
GKE56_RS13550 2812306..2812908 + 603 WP_154684979.1 TetR family transcriptional regulator -
GKE56_RS13555 2812921..2813250 - 330 WP_154684980.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GKE56_RS13560 2813247..2813495 - 249 WP_154684981.1 antitoxin MazE5 Antitoxin
GKE56_RS13565 2813601..2814242 - 642 WP_154684982.1 DNA-3-methyladenine glycosylase -
GKE56_RS13570 2814410..2816299 + 1890 WP_154684983.1 molecular chaperone DnaK -
GKE56_RS13575 2816296..2816928 + 633 WP_154684984.1 nucleotide exchange factor GrpE -
GKE56_RS13580 2816973..2818025 + 1053 WP_154684985.1 DnaJ domain-containing protein -
GKE56_RS13585 2817991..2818443 + 453 WP_154684986.1 MerR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11584.48 Da        Isoelectric Point: 8.0269

>T143677 WP_154684980.1 NZ_CP046121:c2813250-2812921 [Tetrasphaera sp. HKS02]
VTSLPQRGEVWWCELPQVGRRPALVLSRDAAITGRRRAIIAPCTTTVRGLLTEVELHPSTDPVPRPCVASLDAVENVSVA
LLVDRIGRVSEARMSQACAALAVATGCAL

Download         Length: 330 bp

>T143677 NZ_CP061318:c708963-708673 [Polynucleobacter sp. AP-Ainpum-60-G11]
ATGATCGAAATTAGAAAAACTGAAGAATTCATAGTTTGGCTAGATAACTTATTTGATTTGTTGGCAAGAGCAAAGATGCA
GGCAAGAATCAAAAGGCTATCCGAAGGAAATCCAGGTAATGCTGAATCTGTAGGTGAAAAGGTATTCGAGATGAAGATTG
ATTTTGGTCCTGGTTATCGGGTGTATTACACCAAACATGGTCAGACACTCACCATTCTTTTATTGGGCGGAGATAAGAAA
ACACAAGCCAGAGATATCAAACTAGCTCAACGTTTAGCGAGAAATTTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8972.92 Da        Isoelectric Point: 5.0474

>AT143677 WP_154684981.1 NZ_CP046121:c2813495-2813247 [Tetrasphaera sp. HKS02]
MAKARLSTTVDSELLNRARTVHGKHTDASLLEAALTAYLAQHRDAEIDAAYAKAYAEHPIDEPDAWGDLASWSDALRVAD
PR

Download         Length: 249 bp

>AT143677 NZ_CP061318:c708663-708361 [Polynucleobacter sp. AP-Ainpum-60-G11]
ATGAAAAGAACAATCACAACCCCATATGATGTCGCTGAGCATCTTCGCACCCCAAAAGAAATGGCCGCCTACCTAGAGGC
TTGCATAGAAGAGGCAGATGGTGACGCCGCTTTTATTGCTAAGGCACTAGGTGACATTGCAAGAGCCAAAGGGATGACTC
AAGTTGCTAAAGATTCGGGCCTGACAAGAGAGAGCTTATATAAATCACTTTCTGGCGAGAGAAGTCCAGGCTTTGACACC
ATACTGAAAGTTATTGCTGCATTGGGCTTAAGCCTTCATGCTGCACCCGCCATCAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References