Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3621253..3621890 Replicon chromosome
Accession NZ_CP046120
Organism Novosphingobium sp. Gsoil 351

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GKE62_RS17435 Protein ID WP_154693334.1
Coordinates 3621498..3621890 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GKE62_RS17430 Protein ID WP_154693333.1
Coordinates 3621253..3621501 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKE62_RS17400 3616493..3616702 - 210 WP_154693329.1 DUF2945 domain-containing protein -
GKE62_RS17405 3616914..3617562 + 649 Protein_3447 DsbA family protein -
GKE62_RS17410 3617559..3618002 + 444 WP_154693330.1 GFA family protein -
GKE62_RS17415 3618038..3618745 + 708 WP_154693799.1 alpha/beta fold hydrolase -
GKE62_RS17420 3618832..3620652 + 1821 WP_154693331.1 M2 family metallopeptidase -
GKE62_RS17425 3620715..3621182 + 468 WP_195908504.1 YbjN domain-containing protein -
GKE62_RS17430 3621253..3621501 + 249 WP_154693333.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GKE62_RS17435 3621498..3621890 + 393 WP_154693334.1 type II toxin-antitoxin system VapC family toxin Toxin
GKE62_RS17440 3621891..3623328 - 1438 Protein_3454 AMP nucleosidase -
GKE62_RS17445 3623521..3624375 - 855 WP_154693335.1 cupin-like domain-containing protein -
GKE62_RS17450 3624950..3625312 + 363 WP_154693336.1 30S ribosomal protein S6 -
GKE62_RS17455 3625316..3625540 + 225 WP_154693337.1 30S ribosomal protein S18 -
GKE62_RS17460 3625553..3626164 + 612 WP_154693338.1 50S ribosomal protein L9 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-126)

Antitoxin

Antitoxin VapB-like

(1-81)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14205.02 Da        Isoelectric Point: 4.4742

>T143676 WP_154693334.1 NZ_CP046120:3621498-3621890 [Novosphingobium sp. Gsoil 351]
VIVDSSALIAMLNKEAGYQRLARALVDSEALPQIASGNFLETAIVADGRRDPVLSRRFDDLLDQFDIEIVSFTPELAEIA
RQAYRDFGKGSGHPAKLNFGDCMAYALARSEGKPLLYVGNDFTHTDIEAA

Download         Length: 393 bp

>T143676 NZ_CP061318:c708663-708361 [Polynucleobacter sp. AP-Ainpum-60-G11]
ATGAAAAGAACAATCACAACCCCATATGATGTCGCTGAGCATCTTCGCACCCCAAAAGAAATGGCCGCCTACCTAGAGGC
TTGCATAGAAGAGGCAGATGGTGACGCCGCTTTTATTGCTAAGGCACTAGGTGACATTGCAAGAGCCAAAGGGATGACTC
AAGTTGCTAAAGATTCGGGCCTGACAAGAGAGAGCTTATATAAATCACTTTCTGGCGAGAGAAGTCCAGGCTTTGACACC
ATACTGAAAGTTATTGCTGCATTGGGCTTAAGCCTTCATGCTGCACCCGCCATCAAGAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8919.26 Da        Isoelectric Point: 9.9628

>AT143676 WP_154693333.1 NZ_CP046120:3621253-3621501 [Novosphingobium sp. Gsoil 351]
MNLNIKSAETHRLAVQLAKETGDSITGAVTKAIRAELRKREDKQAKLARIEKILEYTSKALRGGPGSADIDALLYDEAGL
PK

Download         Length: 249 bp

>AT143676 NZ_CP061318:c708963-708673 [Polynucleobacter sp. AP-Ainpum-60-G11]
ATGATCGAAATTAGAAAAACTGAAGAATTCATAGTTTGGCTAGATAACTTATTTGATTTGTTGGCAAGAGCAAAGATGCA
GGCAAGAATCAAAAGGCTATCCGAAGGAAATCCAGGTAATGCTGAATCTGTAGGTGAAAAGGTATTCGAGATGAAGATTG
ATTTTGGTCCTGGTTATCGGGTGTATTACACCAAACATGGTCAGACACTCACCATTCTTTTATTGGGCGGAGATAAGAAA
ACACAAGCCAGAGATATCAAACTAGCTCAACGTTTAGCGAGAAATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References