Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/couple_hipB(antitoxin)
Location 2977617..2978217 Replicon chromosome
Accession NZ_CP046120
Organism Novosphingobium sp. Gsoil 351

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GKE62_RS14400 Protein ID WP_154692840.1
Coordinates 2977969..2978217 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GKE62_RS14395 Protein ID WP_154692839.1
Coordinates 2977617..2977958 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKE62_RS14380 2975334..2976709 + 1376 Protein_2848 3-deoxy-7-phosphoheptulonate synthase class II -
GKE62_RS14385 2976846..2977076 - 231 WP_154692837.1 hypothetical protein -
GKE62_RS14390 2977107..2977301 - 195 WP_154692838.1 hypothetical protein -
GKE62_RS14395 2977617..2977958 - 342 WP_154692839.1 helix-turn-helix transcriptional regulator Antitoxin
GKE62_RS14400 2977969..2978217 - 249 WP_154692840.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GKE62_RS14405 2978733..2979755 + 1023 WP_154692841.1 cysteine synthase A -
GKE62_RS14410 2979762..2980133 + 372 WP_154692842.1 hypothetical protein -
GKE62_RS14415 2980147..2980869 + 723 WP_154692843.1 ABC transporter -
GKE62_RS14420 2981202..2981696 + 495 WP_154692844.1 division/cell wall cluster transcriptional repressor MraZ -
GKE62_RS14425 2981693..2982640 + 948 WP_154692845.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
GKE62_RS14430 2982637..2983197 + 561 WP_154692846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(61-112)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8834.23 Da        Isoelectric Point: 11.0756

>T143675 WP_154692840.1 NZ_CP046120:c2978217-2977969 [Novosphingobium sp. Gsoil 351]
VKPITYTRAAIKVLRRMPANTSARIVGKIEAYATDPASQANNVTALQGRDGIRLRVGDWRVIMNDGAVLAVLQVGPRGGV
YD

Download         Length: 249 bp

>T143675 NZ_CP061318:c264083-263793 [Polynucleobacter sp. AP-Ainpum-60-G11]
TTGAAGACCTATAGTCTTGAGTTCAATGTACTTGCTTTAAAAGAGTGGCAAAAATTAGATAACTCAGTTCGTAGCCAGTT
CAAAAAACAGCTAGAGAAACGAATTCAAAATCCTAGAATTGCTTCCGCCAAGTTACATGGTGACCTGGATAATTTCTATA
AGATAAAACTTGCAGCACTTGGCTATAGATTAGTTTATGAAGTAATTGACCATAAACTTGTCGTTCTTATTATTGCAGTT
GGCAAGAGAAATCAGTCAGCCGTTTACAAAGCAGCCAGCAAAAGAAAATAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 11679.40 Da        Isoelectric Point: 5.8375

>AT143675 WP_154692839.1 NZ_CP046120:c2977958-2977617 [Novosphingobium sp. Gsoil 351]
MGEMVTIPAAEYQALLGAATNLADLRAHDRAMAAIARGDEELVPAAFAKRLIAGESPVRVWRELRGLTQAALAATSGVNR
VQIANIESGAKSGSVATLRKLADALGVGLDDLA

Download         Length: 342 bp

>AT143675 NZ_CP061318:c264324-264070 [Polynucleobacter sp. AP-Ainpum-60-G11]
ATGACAATCACGCAAACTATTCATGCCAAAACCACAGTCAGCATGACTGACCTTAGGCGTAATCCGAGCAAAATTTTAGA
GATTGCTGGCGACCTACCTGTAGCTGTACTGAATCACAACAAACCAGAGGCCTATTTACTGTCGGCAAAAGCATATGAAG
CACTTCTAGACTTAGTAGATGATCTCTCACTCATCAAAATTATTAAGGCACGCAATAGCGGAAAAACTGTGAAAGTAAAA
CTTGAAGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References