Detailed information of TA system TA143651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4642627..4644325
• Replicon: chromosome
• Accession: NZ_CP046115
• Organism: Klebsiella oxytoca strain P620

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: GJ746_RS21625
• Protein ID: WP_154682032.1
• Coordinates: 4643396..4644325 (+)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: GJ746_RS21620
• Protein ID: WP_195908765.1
• Coordinates: 4642627..4643409 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJ746_RS21595	4638085..4640223	-	2139	WP_154682029.1	ornithine decarboxylase	-
GJ746_RS21600	4640655..4641371	+	717	WP_154682030.1	DUF554 domain-containing protein	-
GJ746_RS21610	4641796..4642002	-	207	WP_154682031.1	helix-turn-helix domain-containing protein	-
GJ746_RS21615	4641999..4642190	-	192	Protein_4213	hypothetical protein	-
GJ746_RS21620	4642627..4643409	+	783	WP_195908765.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
GJ746_RS21625	4643396..4644325	+	930	WP_154682032.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GJ746_RS21630	4644985..4645686	-	702	WP_154682033.1	fimbria/pilus periplasmic chaperone	-
GJ746_RS21635	4645795..4646967	-	1173	WP_154682034.1	type 1 fimbrial protein	-
GJ746_RS21640	4646989..4647687	-	699	WP_154682035.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-224)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-92)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35040.38 Da
• Isoelectric Point: 6.7502

>T143651 WP_154682032.1 NZ_CP046115:4643396-4644325 [Klebsiella oxytoca]
MDLHDSYARQVRLLMTALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTYADRDTDLAAINDALMRITGSLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPTEMPVCEQVEMEYGFTTMNVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPITELLAPNWDTARITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDRDRQFLLSYKQNTPAWSLYRYPEIQHLPAIRWKSRNLEVLKDKNPAKYAAAVNKLERVLEQYL

Nucleotide

• Length: 930 bp

>T143651 NZ_CP061302:1140117-1140431 [Polynucleobacter sp. MG-Unter2-18]
ATGAAAGCCGTTAAAGAGATAAAGAAAACCAAGATCGATGCACTGCCTAACTTTGACATGGCGCGCTATTTAAATAGTGA
TAAAGCGATAACGGAATACTTGAACCAGGTGCTTGAAGAAGGTGATGATGCATTATTAGCGGAGGCTCTTGGGGATATTG
CCAGAGCTAAAGGTATGGCGCAAATTGCCCAAACTACAGGCATTACCCGTGAGGCACTTTATAAGGCGCTAAGACCAAAT
GCTAAACCCCGTTTTGATACCATTAGTAAGGTTATTGGGGCTCTAGGCATTAAATTGGTTGCACAAAGAATTTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29289.64 Da
• Isoelectric Point: 8.1216

>AT143651 WP_195908765.1 NZ_CP046115:4642627-4643409 [Klebsiella oxytoca]
MPNYLNWLMQNTLPGQVLLQSWLARNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLVLQGHAHYIEPGKQQIWLALSAYVKLPGWFVTFEQSATFVTLYTSGLTVDIPSFTTQLKIGDRLLAGSVPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNEHPYFQYLDQSSIETGSGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT143651 NZ_CP061302:1139821-1140120 [Polynucleobacter sp. MG-Unter2-18]
ATGTACACGGTTAAAGAAACACCAGAATTCCAAGATTGGCTTGATAACATTCGCGATCTCAAAACAAGAATCCGACTAGC
CAAACGCCTAGTAAAGGTACGGAACGGTACCATGGGGGATATAGAGCCGGTAGGTGATGGAATAAGTGAAATGCGTGAGC
ATTTTGGCCCAGGATGGCGAATGTATTACATAAAGCAGGGAAAAGTCATTATTGTGATGTTAGGTGGCGGAGATAAATCG
ACCCAAACAGCAGACATTAAGGCAGTTAAAAGAATGCTAAAAACGTTGGAGGAATCATGA