Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4563852..4564509 Replicon chromosome
Accession NZ_CP046115
Organism Klebsiella oxytoca strain P620

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag GJ746_RS21220 Protein ID WP_154681968.1
Coordinates 4563852..4564262 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag GJ746_RS21225 Protein ID WP_154681969.1
Coordinates 4564243..4564509 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ746_RS21200 4559829..4561562 - 1734 WP_154681964.1 single-stranded-DNA-specific exonuclease RecJ -
GJ746_RS21205 4561568..4562281 - 714 WP_154681965.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GJ746_RS21210 4562304..4563200 - 897 WP_154681966.1 site-specific tyrosine recombinase XerD -
GJ746_RS21215 4563322..4563843 + 522 WP_154681967.1 flavodoxin FldB -
GJ746_RS21220 4563852..4564262 - 411 WP_154681968.1 protein YgfX Toxin
GJ746_RS21225 4564243..4564509 - 267 WP_154681969.1 FAD assembly factor SdhE Antitoxin
GJ746_RS21230 4564754..4565737 + 984 WP_154681970.1 tRNA-modifying protein YgfZ -
GJ746_RS21235 4565849..4566508 - 660 WP_154681971.1 hemolysin III family protein -
GJ746_RS21240 4566671..4566982 - 312 WP_154681972.1 N(4)-acetylcytidine aminohydrolase -
GJ746_RS21245 4567033..4567761 + 729 WP_154682792.1 MurR/RpiR family transcriptional regulator -
GJ746_RS21250 4567883..4569316 + 1434 WP_154682793.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.96 Da        Isoelectric Point: 10.9455

>T143650 WP_154681968.1 NZ_CP046115:c4564262-4563852 [Klebsiella oxytoca]
VVLWQSDLRISWRSQWFSLLIHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGIPWVINSGMLLRLRHTENHRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T143650 NZ_CP061302:1139821-1140120 [Polynucleobacter sp. MG-Unter2-18]
ATGTACACGGTTAAAGAAACACCAGAATTCCAAGATTGGCTTGATAACATTCGCGATCTCAAAACAAGAATCCGACTAGC
CAAACGCCTAGTAAAGGTACGGAACGGTACCATGGGGGATATAGAGCCGGTAGGTGATGGAATAAGTGAAATGCGTGAGC
ATTTTGGCCCAGGATGGCGAATGTATTACATAAAGCAGGGAAAAGTCATTATTGTGATGTTAGGTGGCGGAGATAAATCG
ACCCAAACAGCAGACATTAAGGCAGTTAAAAGAATGCTAAAAACGTTGGAGGAATCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.97 Da        Isoelectric Point: 4.8616

>AT143650 WP_154681969.1 NZ_CP046115:c4564509-4564243 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT143650 NZ_CP061302:1140117-1140431 [Polynucleobacter sp. MG-Unter2-18]
ATGAAAGCCGTTAAAGAGATAAAGAAAACCAAGATCGATGCACTGCCTAACTTTGACATGGCGCGCTATTTAAATAGTGA
TAAAGCGATAACGGAATACTTGAACCAGGTGCTTGAAGAAGGTGATGATGCATTATTAGCGGAGGCTCTTGGGGATATTG
CCAGAGCTAAAGGTATGGCGCAAATTGCCCAAACTACAGGCATTACCCGTGAGGCACTTTATAAGGCGCTAAGACCAAAT
GCTAAACCCCGTTTTGATACCATTAGTAAGGTTATTGGGGCTCTAGGCATTAAATTGGTTGCACAAAGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References