Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1360169..1360788 Replicon chromosome
Accession NZ_CP046115
Organism Klebsiella oxytoca strain P620

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag GJ746_RS06345 Protein ID WP_004099646.1
Coordinates 1360169..1360387 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag GJ746_RS06350 Protein ID WP_154679420.1
Coordinates 1360414..1360788 (-) Length 125 a.a.

Genomic Context


GJ746_RS06315GJ746_RS06320GJ746_RS06330GJ746_RS06325GJ746_RS06335GJ746_RS06340GJ746_RS06345GJ746_RS06350GJ746_RS06355GJ746_RS06360
Location: 1356224..1356487 (264 bp)
Type: Others
Protein ID: WP_154679416.1
Location: 1356487..1356627 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1357423..1358877 (1455 bp)
Type: Others
Protein ID: WP_154682658.1
Location: 1356624..1357322 (699 bp)
Type: Others
Protein ID: WP_154679417.1
Location: 1358852..1359322 (471 bp)
Type: Others
Protein ID: WP_154679418.1
Location: 1359440..1360006 (567 bp)
Type: Others
Protein ID: WP_154679419.1
Location: 1360169..1360387 (219 bp)
Type: Toxin
Protein ID: WP_004099646.1
Location: 1360414..1360788 (375 bp)
Type: Antitoxin
Protein ID: WP_154679420.1
Location: 1361272..1364418 (3147 bp)
Type: Others
Protein ID: WP_154679421.1
Location: 1364441..1365634 (1194 bp)
Type: Others
Protein ID: WP_154679422.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GJ746_RS063151356224..1356487+264WP_154679416.1type B 50S ribosomal protein L31-
GJ746_RS063201356487..1356627+141WP_003859006.1type B 50S ribosomal protein L36-
GJ746_RS063251356624..1357322-699WP_154679417.1GNAT family N-acetyltransferase-
GJ746_RS063301357423..1358877+1455WP_154682658.1PLP-dependent aminotransferase family protein-
GJ746_RS063351358852..1359322-471WP_154679418.1YlaC family protein-
GJ746_RS063401359440..1360006-567WP_154679419.1maltose O-acetyltransferase-
GJ746_RS063451360169..1360387-219WP_004099646.1hemolysin expression modulator HhaToxin
GJ746_RS063501360414..1360788-375WP_154679420.1Hha toxicity modulator TomBAntitoxin
GJ746_RS063551361272..1364418-3147WP_154679421.1multidrug efflux RND transporter permease subunit AcrB-
GJ746_RS063601364441..1365634-1194WP_154679422.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T143640 WP_004099646.1 NZ_CP046115:c1360387-1360169 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T143640 NZ_CP061298:325826-326095 [Polynucleobacter paludilacus]
TTGGCCTGGATCATTAAGTACACAGAGTCTTCAAGTAAGCAGCTCAAAAAATTAGATAAGCAAACTGCATTACGCGTACT
AGATTACATGGATGAGCGCGTTGCGGTATTGAATGACCCACGTTCTTTGGGTAAAAATTTAAAAGGCCCCAAGATAGGTG
AATATTGGCGGTACAGAGTGGGCGATATTAGAGTGATCTGCAATATCGTAGACGGACAGATGATGGTCTTAGTGATCGAG
ATTGGAAATCGTCGTGAAGTTTATAGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14364.11 Da        Isoelectric Point: 4.8989

>AT143640 WP_154679420.1 NZ_CP046115:c1360788-1360414 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT143640 NZ_CP061298:325615-325842 [Polynucleobacter paludilacus]
ATGGCTGTTTCAATTCGGCTTGATCCAGAGATTGAGCAAAGATTAGATCAACTAGCTGCACAAACTGGTAGGGCTAAATC
GTATTATTTGCGTGAGTTGATCGAGGGTGGGTTGGATGACCTTGAAGATTTCTATTTGGCAGATGCGGTAATGGAGCGGG
TGCGCAGAGGCAGCGAAAAACTATTAGATGCTACCCAGGTAAGGAAAGATCTTGGCCTGGATCATTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3H713


Antitoxin

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Source
ID
Structure
No matching records found

References