Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1360169..1360788 | Replicon | chromosome |
Accession | NZ_CP046115 | ||
Organism | Klebsiella oxytoca strain P620 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H3N9D8 |
Locus tag | GJ746_RS06345 | Protein ID | WP_004099646.1 |
Coordinates | 1360169..1360387 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | - |
Locus tag | GJ746_RS06350 | Protein ID | WP_154679420.1 |
Coordinates | 1360414..1360788 (-) | Length | 125 a.a. |
Genomic Context
Location: 1356224..1356487 (264 bp)
Type: Others
Protein ID: WP_154679416.1
Type: Others
Protein ID: WP_154679416.1
Location: 1356487..1356627 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Type: Others
Protein ID: WP_003859006.1
Location: 1357423..1358877 (1455 bp)
Type: Others
Protein ID: WP_154682658.1
Type: Others
Protein ID: WP_154682658.1
Location: 1356624..1357322 (699 bp)
Type: Others
Protein ID: WP_154679417.1
Type: Others
Protein ID: WP_154679417.1
Location: 1358852..1359322 (471 bp)
Type: Others
Protein ID: WP_154679418.1
Type: Others
Protein ID: WP_154679418.1
Location: 1359440..1360006 (567 bp)
Type: Others
Protein ID: WP_154679419.1
Type: Others
Protein ID: WP_154679419.1
Location: 1360169..1360387 (219 bp)
Type: Toxin
Protein ID: WP_004099646.1
Type: Toxin
Protein ID: WP_004099646.1
Location: 1360414..1360788 (375 bp)
Type: Antitoxin
Protein ID: WP_154679420.1
Type: Antitoxin
Protein ID: WP_154679420.1
Location: 1361272..1364418 (3147 bp)
Type: Others
Protein ID: WP_154679421.1
Type: Others
Protein ID: WP_154679421.1
Location: 1364441..1365634 (1194 bp)
Type: Others
Protein ID: WP_154679422.1
Type: Others
Protein ID: WP_154679422.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJ746_RS06315 | 1356224..1356487 | + | 264 | WP_154679416.1 | type B 50S ribosomal protein L31 | - |
GJ746_RS06320 | 1356487..1356627 | + | 141 | WP_003859006.1 | type B 50S ribosomal protein L36 | - |
GJ746_RS06325 | 1356624..1357322 | - | 699 | WP_154679417.1 | GNAT family N-acetyltransferase | - |
GJ746_RS06330 | 1357423..1358877 | + | 1455 | WP_154682658.1 | PLP-dependent aminotransferase family protein | - |
GJ746_RS06335 | 1358852..1359322 | - | 471 | WP_154679418.1 | YlaC family protein | - |
GJ746_RS06340 | 1359440..1360006 | - | 567 | WP_154679419.1 | maltose O-acetyltransferase | - |
GJ746_RS06345 | 1360169..1360387 | - | 219 | WP_004099646.1 | hemolysin expression modulator Hha | Toxin |
GJ746_RS06350 | 1360414..1360788 | - | 375 | WP_154679420.1 | Hha toxicity modulator TomB | Antitoxin |
GJ746_RS06355 | 1361272..1364418 | - | 3147 | WP_154679421.1 | multidrug efflux RND transporter permease subunit AcrB | - |
GJ746_RS06360 | 1364441..1365634 | - | 1194 | WP_154679422.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8640.05 Da Isoelectric Point: 8.9008
>T143640 WP_004099646.1 NZ_CP046115:c1360387-1360169 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR
Download Length: 219 bp
>T143640 NZ_CP061298:325826-326095 [Polynucleobacter paludilacus]
TTGGCCTGGATCATTAAGTACACAGAGTCTTCAAGTAAGCAGCTCAAAAAATTAGATAAGCAAACTGCATTACGCGTACT
AGATTACATGGATGAGCGCGTTGCGGTATTGAATGACCCACGTTCTTTGGGTAAAAATTTAAAAGGCCCCAAGATAGGTG
AATATTGGCGGTACAGAGTGGGCGATATTAGAGTGATCTGCAATATCGTAGACGGACAGATGATGGTCTTAGTGATCGAG
ATTGGAAATCGTCGTGAAGTTTATAGATGA
TTGGCCTGGATCATTAAGTACACAGAGTCTTCAAGTAAGCAGCTCAAAAAATTAGATAAGCAAACTGCATTACGCGTACT
AGATTACATGGATGAGCGCGTTGCGGTATTGAATGACCCACGTTCTTTGGGTAAAAATTTAAAAGGCCCCAAGATAGGTG
AATATTGGCGGTACAGAGTGGGCGATATTAGAGTGATCTGCAATATCGTAGACGGACAGATGATGGTCTTAGTGATCGAG
ATTGGAAATCGTCGTGAAGTTTATAGATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14364.11 Da Isoelectric Point: 4.8989
>AT143640 WP_154679420.1 NZ_CP046115:c1360788-1360414 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT143640 NZ_CP061298:325615-325842 [Polynucleobacter paludilacus]
ATGGCTGTTTCAATTCGGCTTGATCCAGAGATTGAGCAAAGATTAGATCAACTAGCTGCACAAACTGGTAGGGCTAAATC
GTATTATTTGCGTGAGTTGATCGAGGGTGGGTTGGATGACCTTGAAGATTTCTATTTGGCAGATGCGGTAATGGAGCGGG
TGCGCAGAGGCAGCGAAAAACTATTAGATGCTACCCAGGTAAGGAAAGATCTTGGCCTGGATCATTAA
ATGGCTGTTTCAATTCGGCTTGATCCAGAGATTGAGCAAAGATTAGATCAACTAGCTGCACAAACTGGTAGGGCTAAATC
GTATTATTTGCGTGAGTTGATCGAGGGTGGGTTGGATGACCTTGAAGATTTCTATTTGGCAGATGCGGTAATGGAGCGGG
TGCGCAGAGGCAGCGAAAAACTATTAGATGCTACCCAGGTAAGGAAAGATCTTGGCCTGGATCATTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3H713 |
Antitoxin
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Source | ID | Structure |
---|---|---|
No matching records found |