Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 635025..635705 Replicon chromosome
Accession NZ_CP046115
Organism Klebsiella oxytoca strain P620

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag GJ746_RS02995 Protein ID WP_154678872.1
Coordinates 635367..635705 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GJ746_RS02990 Protein ID WP_195908835.1
Coordinates 635025..635342 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ746_RS02960 631396..631611 - 216 WP_154678867.1 AlpA family phage regulatory protein -
GJ746_RS02965 631730..632353 - 624 WP_154678868.1 inovirus Gp2 family protein -
GJ746_RS02970 632815..633636 + 822 WP_154678869.1 DUF945 domain-containing protein -
GJ746_RS02975 633718..634188 + 471 WP_154678870.1 antirestriction protein -
GJ746_RS02980 634244..634729 + 486 WP_154682627.1 DNA repair protein RadC -
GJ746_RS02985 634744..634967 + 224 Protein_561 DUF987 domain-containing protein -
GJ746_RS02990 635025..635342 + 318 WP_195908835.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GJ746_RS02995 635367..635705 + 339 WP_154678872.1 TA system toxin CbtA family protein Toxin
GJ746_RS03000 635820..636061 + 242 Protein_564 restriction endonuclease subunit M -
GJ746_RS03005 636152..636334 + 183 WP_105576963.1 hypothetical protein -
GJ746_RS03010 636384..637556 + 1173 WP_154678873.1 RNA methyltransferase -
GJ746_RS03015 637564..639063 + 1500 WP_154678874.1 DNA methylase -
GJ746_RS03020 639093..640478 - 1386 WP_154682628.1 PLD-like domain protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 622272..661111 38839


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12729.65 Da        Isoelectric Point: 8.5195

>T143638 WP_154678872.1 NZ_CP046115:635367-635705 [Klebsiella oxytoca]
MKTLPANQRAAKSCPSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQSHLPSIR

Download         Length: 339 bp

>T143638 NZ_CP061297:597399-597740 [Polynucleobacter asymbioticus]
ATGGCTAAGACTTATATTCCAAATGCAGGGGATATTGTTTGGTTAGAGTTTGATCCTCAAGCTGGGCATGAGCAAGCGGG
GCGACGTCCCGCCGTAGTTTTGACGCCAGAAGCGTATAACAAAAAAACAAATTTGATGATTTGTTGCCCTTTGACTACAA
AAATTAAGGGCTATCCATTTGAAGTTCTGGTGGAAATTGATGGCATTCAATCCGCGATTCTTTCTGATCAGGTTAAATCT
CTGGATTGGAAAACTCGAAAAGCAAAATATAAGGGTGCAGTCAGTACATTTGCTCTTGCTGAGGTGCGAAGTAAGGCTAA
AGCGCTTCTGTCAATAACGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12075.73 Da        Isoelectric Point: 6.7383

>AT143638 WP_195908835.1 NZ_CP046115:635025-635342 [Klebsiella oxytoca]
ISEPWWGLRRNISPCFGARLVQEDNRLHYLADRANFSGQFCDADLRHLDQAFPVLMKQLELMLTSGELNIHHQHCVTLYA
RGLTCEADTLGSHGYVYIAIYPTQR

Download         Length: 318 bp

>AT143638 NZ_CP061297:597157-597399 [Polynucleobacter asymbioticus]
ATGCAAACTATTATTAAAAAGTGGGGCAATAGTCCTGCACTGCGTCTAAATACTGCTGTTATGAAGTCTGCCCACTTGAA
TATTGATCAGATTGTTTCGGTTAAGGTGCAGAGAGGTCGCATCGTTATTGAGCCTATTGTTCAGAAGGAATACCAGCTCG
ATGACTTGCTTGCTGGGATAACTGCGAAAAATATTCATCATGAAAATGATTTTGGTGAGCCCGTAGGTAAAGAATTGCTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References