Detailed information of TA system TA143637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1913361..1915048
• Replicon: chromosome
• Accession: NZ_CP046114
• Organism: Glaesserella parasuis strain SCW0912

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GJV39_RS09640
• Protein ID: WP_021110343.1
• Coordinates: 1913705..1915048 (-)
• Length: 448 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GJV39_RS09635
• Protein ID: WP_015940035.1
• Coordinates: 1913361..1913705 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV39_RS09615	1909429..1910379	-	951	WP_005713153.1	ribose-phosphate pyrophosphokinase	-
GJV39_RS09620	1910407..1911252	-	846	WP_021110346.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
GJV39_RS09625	1911254..1911886	-	633	WP_021110345.1	lipoprotein insertase outer membrane protein LolB	-
GJV39_RS09630	1912007..1913332	-	1326	WP_021110344.1	ATP-dependent RNA helicase SrmB	-
GJV39_RS09635	1913361..1913705	-	345	WP_015940035.1	helix-turn-helix domain-containing protein	Antitoxin
GJV39_RS09640	1913705..1915048	-	1344	WP_021110343.1	type II toxin-antitoxin system HipA family toxin	Toxin
GJV39_RS09645	1915162..1915599	-	438	WP_021110342.1	ribosomal protein S18-alanine N-acetyltransferase	-
GJV39_RS09650	1915841..1916281	-	441	WP_016528419.1	M23 family metallopeptidase	-
GJV39_RS09655	1916283..1916696	-	414	WP_005713136.1	DNA polymerase III subunit psi	-
GJV39_RS09660	1916779..1917720	+	942	WP_005713135.1	16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC	-
GJV39_RS09665	1917870..1920047	+	2178	WP_021110341.1	bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (161-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 448 a.a.
• Molecular weight: 51032.99 Da
• Isoelectric Point: 5.0229

>T143637 WP_021110343.1 NZ_CP046114:c1915048-1913705 [Glaesserella parasuis]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPYRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPTAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSAIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIENSHLVETGMAFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKSHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Nucleotide

• Length: 1344 bp

>T143637 NZ_CP061297:551454-551777 [Polynucleobacter asymbioticus]
ATGACCTACACCATTAGCTATTACAGCCCCGATGTATTGGAGCAAATTTTTGATTTACCTATTTCTTTGCAGGCACGCTA
CATTGCTTTGACACAGCGGATGATTGAATATGGGCCGCATTTAGGTTTGCCACATACCGATTCGTTTGGAAGTGGTTTAT
TTGAGCTTAGGCTAAAGGGTATTGAGGGGATTGCAAGAGTTTTCTTTTGTACCGTGGTGGAGCGGGAGATTGTGATGTTG
CATAGCTTTATTAAGAAATCGCAGAAAACTCCCAATAAAGAATTAAGGCTGGCTAAGTTGAGAATGAGGGAAGTGAAATT
ATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13225.52 Da
• Isoelectric Point: 10.2782

>AT143637 WP_015940035.1 NZ_CP046114:c1913705-1913361 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Nucleotide

• Length: 345 bp

>AT143637 NZ_CP061297:551774-552073 [Polynucleobacter asymbioticus]
ATGAAGACAAAGACATTGACCCATAAACAAGCAGTTAGCAAGATGTTAAAAAATCCAGCAGTCAAGGCTGAAGTCGAGCG
TTTAAATAAAGAGGAGTTTGCTATTCTTGATGAAATACTGCAGGCTCGTAAAGCCGCAGGTTTATCTCAGGCTGAAGTGG
CTCGCAGAATGGGTACACAAGCTCCTGCTATAGCAAGGCTCGAAAGCTCTTTGGCAACTGGAAAGCACTCCCCAAGTTTA
AGTACGCTCCGAAAGTATGCTGCTGCCTTAGGTAAGAGAGTCGAATTACACCTAGTCTGA