Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 1606652..1607187 Replicon chromosome
Accession NZ_CP046114
Organism Glaesserella parasuis strain SCW0912

Toxin (Protein)


Gene name relE Uniprot ID A0A836YZW4
Locus tag GJV39_RS08140 Protein ID WP_016528228.1
Coordinates 1606652..1606936 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag GJV39_RS08145 Protein ID WP_010785924.1
Coordinates 1606933..1607187 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV39_RS08120 1602283..1602774 + 492 WP_016528224.1 acetolactate synthase small subunit -
GJV39_RS08125 1602881..1603702 - 822 WP_021110404.1 PHP domain-containing protein -
GJV39_RS08130 1603851..1604810 - 960 WP_021110405.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
GJV39_RS08135 1604893..1606443 - 1551 WP_021110406.1 exodeoxyribonuclease I -
GJV39_RS08140 1606652..1606936 - 285 WP_016528228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJV39_RS08145 1606933..1607187 - 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
GJV39_RS08150 1607305..1608060 - 756 WP_012621503.1 ABC transporter permease -
GJV39_RS08155 1608082..1608978 - 897 WP_021110407.1 ABC transporter ATP-binding protein -
GJV39_RS08160 1608984..1611002 - 2019 WP_021110408.1 DNA polymerase III subunit gamma/tau -
GJV39_RS08165 1611090..1611632 - 543 WP_005712695.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11276.27 Da        Isoelectric Point: 10.5362

>T143635 WP_016528228.1 NZ_CP046114:c1606936-1606652 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
RERNDVYQKVQLRL

Download         Length: 285 bp

>T143635 NZ_CP061296:1090147-1090455 [Polynucleobacter sp. MWH-P3-07-1]
ATGAAAAAGACAATTATTAGTCCTTATGATGTAGTGGAGCACTTACGTACCCCAAAGGAAATGGCGCTTTATCTACAAGC
ATGTATTGAAGAATCCGATGGGGATGCGGCGTTTATAGCAAAAGCACTTGGTGATATAGCGCGCGCAAAAGGAATGGCTC
AGGTAGCCAAGGAATCCGGGCTCTCAAGAGAAAGTCTTTATAAAGCTTTGTCTGGCGATCGAATACCGGGGTTTGATACT
GTATTAAAGGTGCTGGCAGCTCTTGGTCTGAGCCTCCATACAAAACCCACTAGTAAAGCTCGTGCTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT143635 WP_010785924.1 NZ_CP046114:c1607187-1606933 [Glaesserella parasuis]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT143635 NZ_CP061296:1089908-1090150 [Polynucleobacter sp. MWH-P3-07-1]
ATGGGAAGAGCAAAAATTCAAGCCAGAATTAAACGTTTAGTCGAAGGAAACCCAGGAAATACAAAATCCGTTGGCGGTAA
AGTTTTTGAGATGAAGATTGATTTTGGGCCTGGCTACAGGATTTATTACACAAAATATGAGGATGTGATGTATCTATTAC
TGATCGGAGGCAATAAAAGAACTCAGAGTAAAGATATTCAGATTGCAAAATATTTAGCCAAAAACATACAGGCAATGAGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZW4

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References