Detailed information of TA system TA143631

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 943656..944278
• Replicon: chromosome
• Accession: NZ_CP046114
• Organism: Glaesserella parasuis strain SCW0912

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A836YYE8
• Locus tag: GJV39_RS04775
• Protein ID: WP_005715063.1
• Coordinates: 944096..944278 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A837B0B6
• Locus tag: GJV39_RS04770
• Protein ID: WP_005715065.1
• Coordinates: 943656..944069 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV39_RS04735	939522..940205	-	684	WP_021109615.1	helix-turn-helix transcriptional regulator	-
GJV39_RS04740	940336..940536	+	201	WP_016527563.1	helix-turn-helix domain-containing protein	-
GJV39_RS04745	940557..940832	+	276	WP_021109614.1	bacteriophage CII family protein	-
GJV39_RS04750	940816..941598	+	783	WP_021109626.1	Rha family transcriptional regulator	-
GJV39_RS04755	941595..942425	+	831	WP_035497995.1	hypothetical protein	-
GJV39_RS04760	942425..943099	+	675	WP_051502669.1	hypothetical protein	-
GJV39_RS04765	943194..943622	+	429	WP_035498003.1	recombination protein NinB	-
GJV39_RS04770	943656..944069	-	414	WP_005715065.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GJV39_RS04775	944096..944278	-	183	WP_005715063.1	type II toxin-antitoxin system HicA family toxin	Toxin
GJV39_RS04780	944525..945094	+	570	WP_035497972.1	recombination protein NinG	-
GJV39_RS04785	945196..946404	+	1209	WP_021109463.1	IS256 family transposase	-
GJV39_RS04790	946411..946791	+	381	WP_035498288.1	antitermination protein	-
GJV39_RS04800	946976..948184	-	1209	WP_035498286.1	IS256 family transposase	-
GJV39_RS04805	948232..948573	-	342	Protein_910	type II toxin-antitoxin system HicB family antitoxin	-
GJV39_RS04810	948603..948788	-	186	WP_005714898.1	type II toxin-antitoxin system HicA family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	930099..1017941	87842

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6678.80 Da
• Isoelectric Point: 10.6602

>T143631 WP_005715063.1 NZ_CP046114:c944278-944096 [Glaesserella parasuis]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Nucleotide

• Length: 183 bp

>T143631 NZ_CP061295:1656646-1657050 [Polynucleobacter sp. MWH-S4W17]
ATGAACGCTAAGAAGATATTTTTTGATACCAATACCCTACTTTATTTACTGTCATCAGATACCAAAAAAGCAGACTGGGT
TACTAAAAATTTACAGCAATCGAACGTAATAAGCGTTCAAGTGCTTAATGAATTTACTTCTGCTAGCATTAGAAAAATAA
AAATATCTAATAGTGAGCTGGATGAATTCTTAGATTTATTTACGTCTACATTCAACGTAAGATCGCTTGACATAGATACT
TTTGAAACTGGATTGATGGTGTCCAGGCGATATGGATACCATCACTATGATTCAATGATTATTGCTGCGGCTTTGCAAGC
AGGATGCGAAAAACTGTACTCAGAAGATATGCAGCACCGGCAAGTAATTGATAAGAGACTGCAGATCGTGAATCCTTTTT
TATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15401.47 Da
• Isoelectric Point: 4.3988

>AT143631 WP_005715065.1 NZ_CP046114:c944069-943656 [Glaesserella parasuis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEEIPMPTSIDNHRKNPDFAEYDFFF
GFVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Nucleotide

• Length: 414 bp

>AT143631 NZ_CP061295:1656426-1656656 [Polynucleobacter sp. MWH-S4W17]
ATGGTCGTATCAAAATGGGGGAACAGCCTTGCCATTCGTCTACCAGCTCAAGTGGTCGAATTTTTAGAGCTAAAAGAAGG
GGATGACATTGAGGTCCATGTTGCGGATAAAAAGCATTTCCAAGTTAAGAAGAAACCTTCCCTGCAGGATAGGCTTCAAA
GTTTGAGAAAATTTCGTGGTCGCATGCCCGCTGATTTTCACTTTGATAGATCTGAATTGAATGAACGCTAA

Structures

Toxin

• AlphaFold DB: A0A836YYE8

Antitoxin

• AlphaFold DB: A0A837B0B6