Detailed information of TA system TA143630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 863736..864513
• Replicon: chromosome
• Accession: NZ_CP046114
• Organism: Glaesserella parasuis strain SCW0912

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: GJV39_RS04370
• Protein ID: WP_021109671.1
• Coordinates: 863736..864236 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: GJV39_RS04375
• Protein ID: WP_005710653.1
• Coordinates: 864226..864513 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV39_RS04335	858861..859016	-	156	WP_021109675.1	YoaH family protein	-
GJV39_RS04340	859034..859762	-	729	WP_021109674.1	tRNA pseudouridine(65) synthase TruC	-
GJV39_RS04345	859759..860073	-	315	WP_005710664.1	YqcC family protein	-
GJV39_RS04350	860115..861029	-	915	WP_021109673.1	N-acetylmuramic acid 6-phosphate etherase	-
GJV39_RS04355	861041..862156	-	1116	WP_021109672.1	anhydro-N-acetylmuramic acid kinase	-
GJV39_RS04360	862311..862646	-	336	WP_005710658.1	outer membrane protein assembly factor BamE	-
GJV39_RS04365	862707..863708	-	1002	WP_005710656.1	nucleoid-associated protein YejK	-
GJV39_RS04370	863736..864236	-	501	WP_021109671.1	GNAT family N-acetyltransferase	Toxin
GJV39_RS04375	864226..864513	-	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
GJV39_RS04380	864659..865048	+	390	WP_021109670.1	RidA family protein	-
GJV39_RS04385	865052..865789	+	738	WP_021109669.1	peptidoglycan editing factor PgeF	-
GJV39_RS04390	865964..867541	+	1578	WP_021109668.1	FAD-binding protein	-
GJV39_RS04395	867645..868145	+	501	WP_021109667.1	CvpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19155.30 Da
• Isoelectric Point: 8.9912

>T143630 WP_021109671.1 NZ_CP046114:c864236-863736 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYSRQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
DYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T143630 NZ_CP061295:c1120091-1118751 [Polynucleobacter sp. MWH-S4W17]
ATGGCAGCTCGCACAAAATCAAGAGGCCTAACCATTTGGATGAATGGTGTTCAAGTGGGCACTTGGCAAATCACAAGACA
ACTTGAAAGCTTCTCCTATTCTAATGAATGGATTATGCGGGCAGAAGCAAGACCCTTATCGCTATCTCTTCCTTTCTTGC
CGGGTAATGCGGCGCATCAAGGCGATCCTGTTAATTATTATTTTGATAACTTATTGCCTGATAGTGACGTGATTCGTAGG
AGGTTAGCGAGTCGTTATCAGGTAAAAAGTTTGGGCGCCTTTGACTTGTTATCTCAGCTTGGTCGCGATTGTGTTGGGGC
TATACAGCTCCTGCCCGATGGTGAGTTGCCAGCAGAAATTTATCAAATTCAAGGTCGAGCATTGAGTAATGAGGAGATTG
CAGATCATCTTCGTCGCGTCTCGTCGGATTCAGTTTTCAGGCAAGCAGAGCAAAGCAATGATTTAAGACTATCCATAGCC
GGTGCGCAAGAAAAAACTGCGCTACTTAAGTGCGATGGACGTTGGCTCTTGCCTCAAGGTAGCACTCCAACTACACATAT
TTTGAAATTGCCCTTGGGTTTGGTTGGTCATATGCGTGCTGACATGCGCACATCGGTTGAGAATGAGTGGCTCTGCTCTA
AAATTATGGCTGCATATGGTATTCCAACTGCTTCCTGTGAAATTAATTCTTTTGAGGATCAAAAAGTATTGATCATTGAG
CGCTTTGACCGGAGATTAGCTGCTGATGGGCAATGGATTATGCGTCTCCCTCAGGAGGATTTTTGTCAGGCAATGGGCAT
ATCGCCAATGAGCAAATATCAAGCGGATGGAGGTCCGAGTATCACATCTGCAATGAAGTTATTGCTGGGGTCGGTGAACG
CAGAGCAAGATCGAATACATTTTTTTAAAACACAAATTATTTTTTGGATCTTAGCTGCAACTGATGGACATGGTAAAAAC
TTTAGCATTGCGCATCTGCCGGGCTCTCAATACCAAGCAACTCCAATTTATGACGTGTTATCAGCGCACCCAGTAATAGG
TTTTGGGGCAAATCAAATGGCACCCCAAAAAGCGAAGCTAGCAATGGCTGTTCGGGGATCGTCCAACTACTACCTGCTAG
ATAAAATTCACTATAGACACTGGCTGGCTCAGGCTCAGCAGGCAGGTCTTGGTGCTGATGTAGCACAGCAATTAATTGGC
GAAGTTATTGAGATGACTGGGTTTGTCATCAACCAAGTAAGGTCGAGTATTACAGGGCCATTTCCAATGGATGTGGCGGA
GTCAATTTTTATGGGTATGGAAGAGAAGGTCCAAATGTTAGCCTCCCAATTTTCAACCTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT143630 WP_005710653.1 NZ_CP046114:c864513-864226 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT143630 NZ_CP061295:c1120366-1120094 [Polynucleobacter sp. MWH-S4W17]
ATGATTTATCAAATTCAAACCCTAGAGACCTTGAAATTATTCATTAGGGCTTTCCGAAAGCAAAAGGGGGTGACTCAGGC
CGATATGGCGCAAAAGCTCGGAATTAGTCAGCAAGCTTATGCGCGTTTTGAGGGCAATCCGCAATTAGCCACTCTTGAAA
GATTGTTCCTGGTCTTGCGGATCCTGGATGTCAAAATATCACTGGAACAGATTATTAAAAACTCAAAAGAAGCAAAAACC
AACATGAAATCTGAGTCCAAGGAGATTTGGTAG

Structures

Antitoxin

• AlphaFold DB: U4SPD7