Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 599565..600104 Replicon chromosome
Accession NZ_CP046114
Organism Glaesserella parasuis strain SCW0912

Toxin (Protein)


Gene name relE Uniprot ID A0A6I5WQI8
Locus tag GJV39_RS03100 Protein ID WP_005714578.1
Coordinates 599835..600104 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B8F4J9
Locus tag GJV39_RS03095 Protein ID WP_005714576.1
Coordinates 599565..599831 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV39_RS03060 596500..596826 + 327 WP_021109618.1 DUF2190 family protein -
GJV39_RS03065 596819..597124 + 306 WP_005714563.1 phage tail protein -
GJV39_RS03070 597128..597661 + 534 WP_005714565.1 phage tail protein -
GJV39_RS03075 597661..598080 + 420 WP_005714567.1 phage tail protein -
GJV39_RS03080 598083..598748 + 666 WP_010786321.1 hypothetical protein -
GJV39_RS03085 598822..599223 + 402 WP_005714571.1 hypothetical protein -
GJV39_RS03090 599268..599495 + 228 WP_005714573.1 DUF4035 domain-containing protein -
GJV39_RS03095 599565..599831 + 267 WP_005714576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GJV39_RS03100 599835..600104 + 270 WP_005714578.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GJV39_RS03105 600250..600818 - 569 Protein_583 transposase -
GJV39_RS03110 600922..601137 + 216 WP_035498906.1 hypothetical protein -
GJV39_RS03115 601340..601615 + 276 WP_005714514.1 hypothetical protein -
GJV39_RS03120 601671..605045 + 3375 WP_021110225.1 phage tail tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 573448..613660 40212
- flank IS/Tn - - 600250..600636 386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-80)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.03 Da        Isoelectric Point: 6.8591

>T143629 WP_005714578.1 NZ_CP046114:599835-600104 [Glaesserella parasuis]
MLQLSPTNAYKRDFKKIASELMSSAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Download         Length: 270 bp

>T143629 NZ_CP061295:279793-280095 [Polynucleobacter sp. MWH-S4W17]
ATGAAAAAGACAAAAAAAATAAAAATAAAAGATATATCTAAATTTGATGTCGTAGATTACTTAAAAACCGATGCAGATAT
TGCTGGATACTTGACAGCTGTACTAGAAGATGGCGATCCCGCTTTATTTGTAGCTGCTATTGGCGACATTGCCAGAGCAA
AGGGAATGAGCGACATTGCTAAAAAGAGCGGCGTTACTAGAGAGTCCCTTTATAGAGCTTTAAAAATTGAGGCGCGACCA
CGTTTTGAGACTGTGACTAGAGTCATACATGCGTTAGGCATGAGATTAACTGTTCATGCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9945.38 Da        Isoelectric Point: 5.0366

>AT143629 WP_005714576.1 NZ_CP046114:599565-599831 [Glaesserella parasuis]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYESLEA
FHKAMLAE

Download         Length: 267 bp

>AT143629 NZ_CP061295:279490-279792 [Polynucleobacter sp. MWH-S4W17]
ATGTATGAAATCGATAAAACAGTTGAATTTGAACTCTGGCTTAGCTCTATTCGCGACCCTTTAACTCGAGGTAGATTGTT
GGCAAGGTTGCGCAGAGTTGCTTTAGGGAATTTGGGGGACGTTGCTTCAATATCTGAGTCAAACGGGATTTGGGAGATGC
GTGAGCATTTTGGTGCTGGCTGGAGAATGTATTACTTAAGGCGCGGAAGGGTAGTTATCTTAATGTTGGGCGGTGGTTCT
AAAGCAACTCAAAATGCTGATATTAGAAAAGTTAAGCAAATGCTTCTGGCGATGGAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5WQI8

Antitoxin

Source ID Structure
AlphaFold DB B8F4J9

References