Detailed information of TA system TA143628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 132795..134344
• Replicon: chromosome
• Accession: NZ_CP046114
• Organism: Glaesserella parasuis strain SCW0912

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GJV39_RS00585
• Protein ID: WP_021110129.1
• Coordinates: 132795..134111 (-)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A836YYU2
• Locus tag: GJV39_RS00590
• Protein ID: WP_005713287.1
• Coordinates: 134105..134344 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV39_RS00540	127894..128481	+	588	WP_020457627.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
GJV39_RS00545	128737..128916	-	180	Protein_101	disulfide bond formation protein DsbA	-
GJV39_RS00550	128916..129359	-	444	WP_020457625.1	nuclear transport factor 2 family protein	-
GJV39_RS00555	129494..129610	+	117	Protein_103	LysR family transcriptional regulator	-
GJV39_RS00560	129691..130264	-	574	Protein_104	virulence RhuM family protein	-
GJV39_RS00565	130451..130810	-	360	WP_010787368.1	hypothetical protein	-
GJV39_RS00570	130710..131225	+	516	WP_080691048.1	hypothetical protein	-
GJV39_RS00575	131249..132010	+	762	WP_021110131.1	hypothetical protein	-
GJV39_RS00580	132044..132622	+	579	WP_021110130.1	PLP-dependent aminotransferase family protein	-
GJV39_RS00585	132795..134111	-	1317	WP_021110129.1	type II toxin-antitoxin system HipA family toxin	Toxin
GJV39_RS00590	134105..134344	-	240	WP_005713287.1	helix-turn-helix domain-containing protein	Antitoxin
GJV39_RS00595	134492..135319	-	828	WP_021110128.1	alpha/beta hydrolase	-
GJV39_RS00600	135450..136895	+	1446	WP_021110127.1	metalloprotease TldD	-
GJV39_RS00605	137150..137560	+	411	WP_005713295.1	preprotein translocase subunit SecE	-
GJV39_RS00610	137562..138140	+	579	WP_005713298.1	transcription termination/antitermination protein NusG	-
GJV39_RS00615	138266..138520	-	255	WP_005713300.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-404)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 49974.19 Da
• Isoelectric Point: 7.3465

>T143628 WP_021110129.1 NZ_CP046114:c134111-132795 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFSYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Nucleotide

• Length: 1317 bp

>T143628 NZ_CP061295:279490-279792 [Polynucleobacter sp. MWH-S4W17]
ATGTATGAAATCGATAAAACAGTTGAATTTGAACTCTGGCTTAGCTCTATTCGCGACCCTTTAACTCGAGGTAGATTGTT
GGCAAGGTTGCGCAGAGTTGCTTTAGGGAATTTGGGGGACGTTGCTTCAATATCTGAGTCAAACGGGATTTGGGAGATGC
GTGAGCATTTTGGTGCTGGCTGGAGAATGTATTACTTAAGGCGCGGAAGGGTAGTTATCTTAATGTTGGGCGGTGGTTCT
AAAGCAACTCAAAATGCTGATATTAGAAAAGTTAAGCAAATGCTTCTGGCGATGGAGGATTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9068.48 Da
• Isoelectric Point: 9.7687

>AT143628 WP_005713287.1 NZ_CP046114:c134344-134105 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIHPRPEKTEGNDEW

Nucleotide

• Length: 240 bp

>AT143628 NZ_CP061295:279793-280095 [Polynucleobacter sp. MWH-S4W17]
ATGAAAAAGACAAAAAAAATAAAAATAAAAGATATATCTAAATTTGATGTCGTAGATTACTTAAAAACCGATGCAGATAT
TGCTGGATACTTGACAGCTGTACTAGAAGATGGCGATCCCGCTTTATTTGTAGCTGCTATTGGCGACATTGCCAGAGCAA
AGGGAATGAGCGACATTGCTAAAAAGAGCGGCGTTACTAGAGAGTCCCTTTATAGAGCTTTAAAAATTGAGGCGCGACCA
CGTTTTGAGACTGTGACTAGAGTCATACATGCGTTAGGCATGAGATTAACTGTTCATGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A836YYU2