143533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 2678259..2678841 Replicon chromosome
Accession NZ_CP046108
Organism Enterococcus faecalis strain 133170041-3

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag GKQ57_RS12735 Protein ID WP_002355414.1
Coordinates 2678259..2678567 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag GKQ57_RS12740 Protein ID WP_002326825.1
Coordinates 2678569..2678841 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ57_RS12705 2674046..2674978 - 933 WP_002363040.1 tagatose-6-phosphate kinase -
GKQ57_RS12710 2674989..2675504 - 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
GKQ57_RS12715 2675521..2675946 - 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
GKQ57_RS12720 2676434..2677201 + 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
GKQ57_RS12725 2677206..2677706 + 501 Protein_2497 HAD family hydrolase -
GKQ57_RS12730 2677751..2678179 + 429 WP_071623404.1 tyrosine-type recombinase/integrase -
GKQ57_RS12735 2678259..2678567 - 309 WP_002355414.1 zeta toxin family protein Toxin
GKQ57_RS12740 2678569..2678841 - 273 WP_002326825.1 antitoxin Antitoxin
GKQ57_RS12745 2678858..2679073 - 216 WP_002355411.1 peptide-binding protein -
GKQ57_RS12750 2679144..2679998 - 855 WP_002364921.1 ParA family protein -
GKQ57_RS12755 2680106..2681268 + 1163 Protein_2503 IS3 family transposase -
GKQ57_RS12760 2683221..2683622 + 402 WP_002364925.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T143533 WP_002355414.1 NZ_CP046108:c2678567-2678259 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T143533 NZ_CP061185:c3669484-3669149 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT143533 WP_002326825.1 NZ_CP046108:c2678841-2678569 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT143533 NZ_CP061185:c3669732-3669484 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCAGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGAAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References