Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 283164..283735 Replicon chromosome
Accession NZ_CP046108
Organism Enterococcus faecalis strain 133170041-3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GKQ57_RS01325 Protein ID WP_010785112.1
Coordinates 283394..283735 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag GKQ57_RS01320 Protein ID WP_002354773.1
Coordinates 283164..283394 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GKQ57_RS01300 279408..280703 + 1296 WP_002371641.1 AAA family ATPase -
GKQ57_RS01305 280712..281344 + 633 WP_002358972.1 RloB family protein -
GKQ57_RS01310 281411..282403 - 993 WP_002365428.1 biotin--[acetyl-CoA-carboxylase] ligase -
GKQ57_RS01315 282542..282757 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
GKQ57_RS01320 283164..283394 + 231 WP_002354773.1 hypothetical protein Antitoxin
GKQ57_RS01325 283394..283735 + 342 WP_010785112.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GKQ57_RS01330 284106..287720 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13103.35 Da        Isoelectric Point: 8.4667

>T143526 WP_010785112.1 NZ_CP046108:283394-283735 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRCPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T143526 NZ_CP061185:c2003296-2003189 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT143526 WP_002354773.1 NZ_CP046108:283164-283394 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp

>AT143526 NZ_CP061185:2003344-2003410 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGGGTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References