Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 7692..8211 | Replicon | plasmid p3_03A17012 |
Accession | NZ_CP046075 | ||
Organism | Enterococcus faecium strain VRE |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | GJ652_RS00140 | Protein ID | WP_000588503.1 |
Coordinates | 7954..8211 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | GJ652_RS00135 | Protein ID | WP_000388479.1 |
Coordinates | 7692..7961 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJ652_RS00100 | 3257..3673 | - | 417 | WP_001232859.1 | hypothetical protein | - |
GJ652_RS00105 | 3676..3960 | - | 285 | WP_000353844.1 | hypothetical protein | - |
GJ652_RS00110 | 4304..4549 | + | 246 | WP_002311817.1 | hypothetical protein | - |
GJ652_RS00115 | 4850..4936 | - | 87 | WP_106914087.1 | type I toxin-antitoxin system Fst family toxin | - |
GJ652_RS00120 | 5679..6359 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
GJ652_RS00125 | 6435..7001 | + | 567 | Protein_8 | hypothetical protein | - |
GJ652_RS00130 | 7382..7561 | + | 180 | WP_001120991.1 | hypothetical protein | - |
GJ652_RS00135 | 7692..7961 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
GJ652_RS00140 | 7954..8211 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
GJ652_RS00145 | 9198..10517 | - | 1320 | WP_000202380.1 | IS1380-like element IS1678 family transposase | - |
GJ652_RS00150 | 10674..11120 | + | 447 | Protein_13 | hypothetical protein | - |
GJ652_RS00155 | 11275..12594 | + | 1320 | WP_000202380.1 | IS1380-like element IS1678 family transposase | - |
GJ652_RS00160 | 12798..13040 | + | 243 | Protein_15 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..18356 | 18356 | |
- | inside | IScluster/Tn | - | - | 1657..12594 | 10937 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T143517 WP_000588503.1 NZ_CP046075:7954-8211 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T143517 NZ_CP061181:c2286-2038 [Roseomonas sp. 546]
TTGATCCTGACCCGCCCCGCTCTGAAAGACCTCGGCAACGTGCCGAAGCGGGAGCGCGCTCAGCTGACCGCCCGCCTGGA
AGCCATCGCCGCCGCCCCGACCGGCAGCCACGGCAACGTCATTGCCATGAAGGGCGAGCCGGCCGGCCGCCTGCGGGTGC
GCCAGGGCGACTGGCGCGCCATCTTCACCATCGACGGCGACGATGTGGTAGTCATCCGCATCCGCCATCGCAGAGAGGTT
TACGACTGA
TTGATCCTGACCCGCCCCGCTCTGAAAGACCTCGGCAACGTGCCGAAGCGGGAGCGCGCTCAGCTGACCGCCCGCCTGGA
AGCCATCGCCGCCGCCCCGACCGGCAGCCACGGCAACGTCATTGCCATGAAGGGCGAGCCGGCCGGCCGCCTGCGGGTGC
GCCAGGGCGACTGGCGCGCCATCTTCACCATCGACGGCGACGATGTGGTAGTCATCCGCATCCGCCATCGCAGAGAGGTT
TACGACTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT143517 WP_000388479.1 NZ_CP046075:7692-7961 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT143517 NZ_CP061181:c2038-1631 [Roseomonas sp. 546]
ATGGCCCACATTGGACCCCTGGCCGAGACGGCCGACACCGTGACGCTGCGGCGCGCGGACTTCGAAGCCCTGGTGGCGGC
GGCCGAGGACGTGGCCGACCGCGCCAGCTTCGCCGCCTTCGAGGCGCGCGTGGCGCGTGACGGCATGGCGGCGGTCAAGG
CGGATAGCCTGACCCTGCAGGAGGCGGTGCGCATCCTGGACGAAGGCGAAAGCCCGGTGCGGGTGTGGCGCGAGAAGCGC
GGGCTGACCGGCCGCGCCCTGGCCGCGGCAGCGGGTGTCAGCCCGGTGTATCTGTCGGAGATCGAGAACGGCAAGAAGCC
AGGCAGCGCCGCCGCCATCGTGGCGCTGGCCAAGGCGCTGCAGGTGGATGCCGGCGACCTGCTGCCGCCGGCCGCCACGG
ACGACTAG
ATGGCCCACATTGGACCCCTGGCCGAGACGGCCGACACCGTGACGCTGCGGCGCGCGGACTTCGAAGCCCTGGTGGCGGC
GGCCGAGGACGTGGCCGACCGCGCCAGCTTCGCCGCCTTCGAGGCGCGCGTGGCGCGTGACGGCATGGCGGCGGTCAAGG
CGGATAGCCTGACCCTGCAGGAGGCGGTGCGCATCCTGGACGAAGGCGAAAGCCCGGTGCGGGTGTGGCGCGAGAAGCGC
GGGCTGACCGGCCGCGCCCTGGCCGCGGCAGCGGGTGTCAGCCCGGTGTATCTGTCGGAGATCGAGAACGGCAAGAAGCC
AGGCAGCGCCGCCGCCATCGTGGCGCTGGCCAAGGCGCTGCAGGTGGATGCCGGCGACCTGCTGCCGCCGGCCGCCACGG
ACGACTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |