143514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 4977628..4978523 Replicon chromosome
Accession NZ_CP046069
Organism Pseudomonas aeruginosa strain KRP1

Toxin (Protein)


Gene name slvT Uniprot ID A0A318E8F0
Locus tag KRP1_RS23165 Protein ID WP_023093160.1
Coordinates 4977628..4978155 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A318DY98
Locus tag KRP1_RS23170 Protein ID WP_023093161.1
Coordinates 4978152..4978523 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRP1_RS23145 4973421..4975436 - 2016 WP_023093157.1 DNA topoisomerase III -
KRP1_RS23150 4975731..4976114 - 384 WP_004362284.1 single-stranded DNA-binding protein -
KRP1_RS23155 4976111..4976659 - 549 WP_023093158.1 DUF3158 family protein -
KRP1_RS23160 4976656..4977444 - 789 WP_023093159.1 TIGR03761 family integrating conjugative element protein -
KRP1_RS23165 4977628..4978155 - 528 WP_023093160.1 RES family NAD+ phosphorylase Toxin
KRP1_RS23170 4978152..4978523 - 372 WP_023093161.1 hypothetical protein Antitoxin
KRP1_RS23175 4978644..4979837 - 1194 WP_023093162.1 hypothetical protein -
KRP1_RS23180 4979841..4980401 - 561 WP_023093163.1 DUF2857 domain-containing protein -
KRP1_RS23185 4980419..4982077 - 1659 WP_023093164.1 ParB family protein -
KRP1_RS23190 4982070..4982306 - 237 WP_012584779.1 hypothetical protein -
KRP1_RS23195 4982290..4983156 - 867 WP_023093165.1 ParA family protein -
KRP1_RS23200 4983197..4983415 - 219 WP_016446183.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4866716..5009325 142609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19831.28 Da        Isoelectric Point: 5.2440

>T143514 WP_023093160.1 NZ_CP046069:c4978155-4977628 [Pseudomonas aeruginosa]
MILLDLPPGTTLFRAHTPQWASRPTSGAGAAAKGGRFNREGVEALYLSLEEATALREYQQTSPFLPPCTMCSYTVALREL
VDLRQLHRGEPWDELWHDWREDWRHLKFDLHIEPPTWVLGDMVLAQGHTGILFPSQANDGGTNIVVFVDRLRDGNSVEVN
DPDGRLPRDQSSWTR

Download         Length: 528 bp

>T143514 NZ_CP061172:1390562-1390912 [Paenibacillus peoriae]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGTCCTACTGTGATCGTAGCAGCCATCACTGCCCAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATT
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTAGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAAATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13358.05 Da        Isoelectric Point: 6.0705

>AT143514 WP_023093161.1 NZ_CP046069:c4978523-4978152 [Pseudomonas aeruginosa]
MASTAFADVLESVREAGTSRFSATNVADALGLQYQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVLSAASAVQPDTAR
AFFMVKNEPIPTFHHKTLLQLVQEGRTDDAIDYLESISAGFTG

Download         Length: 372 bp

>AT143514 NZ_CP061172:1390304-1390555 [Paenibacillus peoriae]
ATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGCTATGGAAAATTCCAACCGCAGTGAATTTAT
CAGGCAGGCCATGAAGCTGTATGTAGGCGAACGTAAAAAACGTTACATTCGTGAAGCTATGCAGCGTGGATACATGGAAA
TGGCTAAAATTAACTTAACCATGGCATCCGAAGCCTTTCACGCGGAGGAAGATGCAAACAGCACCTTGGGCCGTACAGTT
AGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318E8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A318DY98

References