Detailed information of TA system TA143513

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4554709..4555967
• Replicon: chromosome
• Accession: NZ_CP046069
• Organism: Pseudomonas aeruginosa strain KRP1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KRP1_RS21050
• Protein ID: WP_023114076.1
• Coordinates: 4554709..4555464 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KRP1_RS21055
• Protein ID: WP_003086329.1
• Coordinates: 4555599..4555967 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRP1_RS21040	4549882..4552425	+	2544	WP_009315399.1	acyl-homoserine-lactone acylase QuiP	-
KRP1_RS21045	4552580..4553941	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
KRP1_RS21050	4554709..4555464	-	756	WP_023114076.1	RES family NAD+ phosphorylase	Toxin
KRP1_RS21055	4555599..4555967	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KRP1_RS21060	4556040..4557326	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
KRP1_RS21065	4557382..4558971	-	1590	WP_073659974.1	aldehyde dehydrogenase family protein	-
KRP1_RS21070	4559050..4559526	+	477	WP_003134036.1	elongation factor GreAB	-
KRP1_RS31550	4559529..4559804	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28309.54 Da
• Isoelectric Point: 8.3428

>T143513 WP_023114076.1 NZ_CP046069:c4555464-4554709 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWKL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T143513 NZ_CP061170:3505494-3505754 [Microbacterium sp. HY82]
GTGAGGTACGTCTGGGACGAAGACGCCTGGGCAGATTACGTGTGGTGGCAGGTGCAGGACCGCAAGGTTTTGAAGCGCAT
CAACGCGCTGCTGCGCGATGTTGCACGGAATGGCAATGAGGGAATCGGGAAACCCGAACCGCTGAAGCACGGCTTTCGCG
GGTACTGGTCTCGCCGCATTACCGACGAACATCGTCTCGTCTACAAGATCGTCGACGACGAGGTACGCGTGGCCGCCTGC
CGGTATCACTACGGGCGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT143513 WP_003086329.1 NZ_CP046069:c4555967-4555599 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT143513 NZ_CP061170:3505246-3505497 [Microbacterium sp. HY82]
ATGCGCACCATGAGCTACTCAGAGTCTCGCGCCAACTACGCAGAGACGCTGTCAAAAGTCGTCGATGACCGTGAAGAGGT
TGTCATCACGCGTTCGGGTCACGAACCGGTGGTGATTGTCTCACTCGACGACTACGAGTCACTGAAAGAGACCGCATATC
TTTTGCGCAATCCAGAGAATGCGCGGCGATTGATGCGTTCCATCGAGCGGCTGGACACGGGCGAAGGCACCGAGCGAGAC
CTTGCCGAGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7