143512

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3641135..3642356 Replicon chromosome
Accession NZ_CP046069
Organism Pseudomonas aeruginosa strain KRP1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KRP1_RS16745 Protein ID WP_003160088.1
Coordinates 3641778..3642356 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KRP1_RS16740 Protein ID WP_003088112.1
Coordinates 3641135..3641689 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRP1_RS16715 3636703..3637254 + 552 WP_003102727.1 XRE family transcriptional regulator -
KRP1_RS16720 3637251..3637649 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KRP1_RS16725 3637662..3637985 - 324 WP_003102734.1 multidrug efflux SMR transporter -
KRP1_RS16730 3638316..3638777 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KRP1_RS16735 3638782..3640977 + 2196 WP_003160090.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KRP1_RS16740 3641135..3641689 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
KRP1_RS16745 3641778..3642356 + 579 WP_003160088.1 HD domain-containing protein Toxin
KRP1_RS16750 3642465..3643652 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KRP1_RS16755 3643642..3645813 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
KRP1_RS16760 3645803..3647080 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T143512 WP_003160088.1 NZ_CP046069:3641778-3642356 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T143512 NZ_CP061170:3505246-3505497 [Microbacterium sp. HY82]
ATGCGCACCATGAGCTACTCAGAGTCTCGCGCCAACTACGCAGAGACGCTGTCAAAAGTCGTCGATGACCGTGAAGAGGT
TGTCATCACGCGTTCGGGTCACGAACCGGTGGTGATTGTCTCACTCGACGACTACGAGTCACTGAAAGAGACCGCATATC
TTTTGCGCAATCCAGAGAATGCGCGGCGATTGATGCGTTCCATCGAGCGGCTGGACACGGGCGAAGGCACCGAGCGAGAC
CTTGCCGAGTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT143512 WP_003088112.1 NZ_CP046069:3641135-3641689 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT143512 NZ_CP061170:3505494-3505754 [Microbacterium sp. HY82]
GTGAGGTACGTCTGGGACGAAGACGCCTGGGCAGATTACGTGTGGTGGCAGGTGCAGGACCGCAAGGTTTTGAAGCGCAT
CAACGCGCTGCTGCGCGATGTTGCACGGAATGGCAATGAGGGAATCGGGAAACCCGAACCGCTGAAGCACGGCTTTCGCG
GGTACTGGTCTCGCCGCATTACCGACGAACATCGTCTCGTCTACAAGATCGTCGACGACGAGGTACGCGTGGCCGCCTGC
CGGTATCACTACGGGCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References