Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2706358..2707400 | Replicon | chromosome |
| Accession | NZ_CP046069 | ||
| Organism | Pseudomonas aeruginosa strain KRP1 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | KRP1_RS12800 | Protein ID | WP_003153636.1 |
| Coordinates | 2706825..2707400 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | KRP1_RS12795 | Protein ID | WP_003050245.1 |
| Coordinates | 2706358..2706828 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KRP1_RS12760 | 2701750..2703168 | - | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
| KRP1_RS12765 | 2703158..2704069 | - | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
| KRP1_RS12770 | 2704066..2704758 | - | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
| KRP1_RS12775 | 2704755..2705153 | - | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
| KRP1_RS12780 | 2705165..2705524 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| KRP1_RS12785 | 2705541..2705774 | - | 234 | WP_003090170.1 | TIGR03758 family integrating conjugative element protein | - |
| KRP1_RS12790 | 2705771..2706154 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| KRP1_RS12795 | 2706358..2706828 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| KRP1_RS12800 | 2706825..2707400 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| KRP1_RS12805 | 2707418..2708332 | + | 915 | WP_023114497.1 | AAA family ATPase | - |
| KRP1_RS12810 | 2708329..2708799 | + | 471 | WP_023114496.1 | hypothetical protein | - |
| KRP1_RS12815 | 2708796..2709296 | + | 501 | WP_003090159.1 | hypothetical protein | - |
| KRP1_RS12820 | 2709296..2710198 | + | 903 | WP_003090158.1 | nucleotidyltransferase domain-containing protein | - |
| KRP1_RS12825 | 2710237..2710962 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2631793..2753516 | 121723 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T143511 WP_003153636.1 NZ_CP046069:2706825-2707400 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T143511 NZ_CP061170:c2445649-2445272 [Microbacterium sp. HY82]
ATGACGTTCGTCGTCGATACGTCAGTTCTCATCGACGTGTTGCGGGGCGAACCGGCTGCTGCGGACGCACTTCATAGCGC
CCGCGGGGCAGGCCCCCTGCATGCAAGCGAGGTCACGCGGCTCGAGGTTCTTGCGGGTATGCGCGCTCCTGAGGAGGTGC
AGACGCGAATGCTCTTCAGCGCTGTGGTGTGGCATCCCGTTGACGAGCACATTGCCGAGATTGCAGGCATTCTCGGGCGG
CGATGGCTTCCACGCAACCGAGGTATCGACTCGGCAGATCTCATAATCGCCGCCACTGCGCAGTCGCTTCATGTGTCGCT
GCTGACCCGAAACGTCAAGCACTTCCCGATGTTCGATGGGCTGACGGCGCCGTACTGA
ATGACGTTCGTCGTCGATACGTCAGTTCTCATCGACGTGTTGCGGGGCGAACCGGCTGCTGCGGACGCACTTCATAGCGC
CCGCGGGGCAGGCCCCCTGCATGCAAGCGAGGTCACGCGGCTCGAGGTTCTTGCGGGTATGCGCGCTCCTGAGGAGGTGC
AGACGCGAATGCTCTTCAGCGCTGTGGTGTGGCATCCCGTTGACGAGCACATTGCCGAGATTGCAGGCATTCTCGGGCGG
CGATGGCTTCCACGCAACCGAGGTATCGACTCGGCAGATCTCATAATCGCCGCCACTGCGCAGTCGCTTCATGTGTCGCT
GCTGACCCGAAACGTCAAGCACTTCCCGATGTTCGATGGGCTGACGGCGCCGTACTGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT143511 WP_003050245.1 NZ_CP046069:2706358-2706828 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT143511 NZ_CP061170:c2445903-2445646 [Microbacterium sp. HY82]
ATGCTTCGCACGCAGATTTCGCTGACGCCCGAGGAGCGACGACTTCTCGACGAAGAGGCTGCGCGAACCGGACGTTCGAT
CTCGGCCCTCATCCGCGACGCTGTCTCGAGCGTCTACGGGTCACAACAGGATGCTGATGCCGACCGCCGCTTGATCGAGG
GCGCGTTCGGTGCGTGGCGTGATCGCGATGTCGACGGCGCGGAGTACGTCGAACGCCTTCGCTCAGGTACCCGCTTGAGT
CAGGCCGCCGAGCGATGA
ATGCTTCGCACGCAGATTTCGCTGACGCCCGAGGAGCGACGACTTCTCGACGAAGAGGCTGCGCGAACCGGACGTTCGAT
CTCGGCCCTCATCCGCGACGCTGTCTCGAGCGTCTACGGGTCACAACAGGATGCTGATGCCGACCGCCGCTTGATCGAGG
GCGCGTTCGGTGCGTGGCGTGATCGCGATGTCGACGGCGCGGAGTACGTCGAACGCCTTCGCTCAGGTACCCGCTTGAGT
CAGGCCGCCGAGCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|