Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1861293..1862801 Replicon chromosome
Accession NZ_CP046069
Organism Pseudomonas aeruginosa strain KRP1

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag KRP1_RS08635 Protein ID WP_003119682.1
Coordinates 1861293..1861880 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag KRP1_RS08640 Protein ID WP_003091607.1
Coordinates 1861947..1862801 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRP1_RS08630 1857548..1861027 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
KRP1_RS08635 1861293..1861880 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
KRP1_RS08640 1861947..1862801 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
KRP1_RS08645 1862898..1865063 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
KRP1_RS08650 1865238..1867112 + 1875 WP_023114549.1 MFS transporter -
KRP1_RS08655 1867173..1867382 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T143510 WP_003119682.1 NZ_CP046069:1861293-1861880 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T143510 NZ_CP061170:1275601-1275882 [Microbacterium sp. HY82]
GTGATCAGATCGTTCGGGAGTAAGGACACCGAACGACTGTGGCGTCGCGAGCGGGTGCCGTCGATCGATCCTCGGATTCA
TTCGGTGGCGCTGCGCAAGCTTCGTCAGGTGGGGTCCGCGGAGTCGCTCGATGATCTCCGTGTCCCACCGGGGAACCGAC
TTGAAGCGCTGAAAGGCAATCGGGCCGGTCAGTACAGCATCAGGATCAATGACCAGTGGCGGATCTGCTTTGTGTGGACA
GTCGCTGGGCCAGAGGAGGTGGAGATCGTTGACTATCACTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT143510 WP_003091607.1 NZ_CP046069:1861947-1862801 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT143510 NZ_CP061170:1275869-1276171 [Microbacterium sp. HY82]
TTGACTATCACTGACAAGATCGAGCCGATCCATCCTGGCGAAGTTCTCATGGAGGACTTCATCGAGGGCTTCGGCATTAC
TCAGAACAAATTGGCGGTCTCGATTGGGGTGCCCCCGCGCAGGATTAACGAGATCGTGCATGGCAAGCGCGCGATCACGG
CTGACACCGCGTTGCGGCTTGGCAAATATTTCGGCACGTCAGCGCAGTTCTGGATCAATCTGCAGGCGCATTACGACCTA
GACCGTGCTGAGGATCGCGTGGCGGATCAGATTGCCGCGATTACACCGTTGACGGTCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References