Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1305668..1306338 Replicon chromosome
Accession NZ_CP046069
Organism Pseudomonas aeruginosa strain KRP1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KRP1_RS06110 Protein ID WP_023114647.1
Coordinates 1305919..1306338 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KRP1_RS06105 Protein ID WP_023114648.1
Coordinates 1305668..1305922 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRP1_RS06085 1301209..1302210 - 1002 WP_031637439.1 hypothetical protein -
KRP1_RS06090 1302295..1302519 + 225 WP_023114650.1 AlpA family phage regulatory protein -
KRP1_RS06095 1302522..1303415 + 894 WP_031637438.1 helicase RepA family protein -
KRP1_RS06100 1303396..1304373 + 978 WP_031637437.1 plasmid replication -
KRP1_RS06105 1305668..1305922 + 255 WP_023114648.1 Arc family DNA-binding protein Antitoxin
KRP1_RS06110 1305919..1306338 + 420 WP_023114647.1 type II toxin-antitoxin system VapC family toxin Toxin
KRP1_RS06115 1306494..1307264 + 771 WP_023114646.1 P-type conjugative transfer protein TrbJ -
KRP1_RS06120 1307278..1307436 + 159 WP_023114645.1 hypothetical protein -
KRP1_RS06125 1307438..1308910 + 1473 WP_023114644.1 P-type conjugative transfer protein TrbL -
KRP1_RS06130 1308979..1309221 + 243 WP_023114643.1 type I toxin-antitoxin system ptaRNA1 family toxin -
KRP1_RS06135 1309233..1309517 + 285 WP_023114642.1 hypothetical protein -
KRP1_RS06140 1309520..1309888 + 369 WP_023114641.1 conjugal transfer transcriptional regulator TraJ -
KRP1_RS06145 1309927..1310385 - 459 WP_023114640.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1301209..1320820 19611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14925.16 Da        Isoelectric Point: 5.1890

>T143509 WP_023114647.1 NZ_CP046069:1305919-1306338 [Pseudomonas aeruginosa]
MIVLDTNVVSEAMKPEPNPAVRAWLNEQVVETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T143509 NZ_CP061170:c1149603-1149211 [Microbacterium sp. HY82]
GTGGCGTACTATCTCGACACGTCGGCGCTTGTAAAACTCGTTGTTGCCGAAGCAGAATCGGCGGCACTTCACGAATGGCT
CACCTCGTGCGAGAGCGAGCTGGTCACGTGCGACCTCGCTCGAACAGAGCTCATGCGTGCAGTGCGGCCCGTCTCGCCTG
ACCGTGCAGTGCGGGCCCGCGAGGTGCTGGAGTCCGTGTTCTCACTGTCCCTATCGACGGCTACGTACGACGCGGCCGCA
CGGCTTCAGCCGCCTGAACTGTGCAGTCTCGACGCCGTCCACCTCGCTGCGGCCCTCGAGCTCGGAGCGGACCTCGAAGG
GATCATCGTGTATGACGGCCACCTCGCTGATGCTGCCGGCTCCTACGGCATCACAACGATCGCTCCGGCGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9508.87 Da        Isoelectric Point: 6.4760

>AT143509 WP_023114648.1 NZ_CP046069:1305668-1305922 [Pseudomonas aeruginosa]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT143509 NZ_CP061170:c1149865-1149605 [Microbacterium sp. HY82]
ATGGATGATGTTGGCATTAGAGCACTGAAGCAAAATGCGTCAGCCGTCGTCGCCTCGGTCGCCGAGGGGCGCTCAGTGAC
GATCACGGATCGAGGGCGCCCGGTCGCACAGCTGTCGCCGCTAGTCTCTGGCGAACTCAATCGCCTCCTGGTGTCTGGTC
GGCTACGCGCGCCTCGGCGCTCGCTCCGAGATCTATCTGTTCCCGCACCGGGCGAACTGACGCCCGCACTGCGAGGTCAG
CGCGACGACGAGCGCTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References