Detailed information of TA system TA143508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 148141..148646
• Replicon: chromosome
• Accession: NZ_CP046069
• Organism: Pseudomonas aeruginosa strain KRP1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KRP1_RS00680
• Protein ID: WP_023114790.1
• Coordinates: 148141..148422 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: KRP1_RS00685
• Protein ID: WP_003083775.1
• Coordinates: 148419..148646 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRP1_RS00655	143392..144741	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
KRP1_RS00660	144790..145476	+	687	WP_003083762.1	FadR family transcriptional regulator	-
KRP1_RS00665	145577..146311	+	735	WP_003117208.1	GntR family transcriptional regulator	-
KRP1_RS00670	146515..146901	+	387	WP_014602345.1	aegerolysin family protein	-
KRP1_RS00675	146933..147841	-	909	WP_003083769.1	LysR family transcriptional regulator	-
KRP1_RS00680	148141..148422	-	282	WP_023114790.1	type II toxin-antitoxin system toxin ParE	Toxin
KRP1_RS00685	148419..148646	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
KRP1_RS00690	148822..149442	-	621	WP_003101226.1	hypothetical protein	-
KRP1_RS00695	149543..150043	+	501	WP_003101228.1	LEA type 2 family protein	-
KRP1_RS00700	150116..150457	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
KRP1_RS00705	150539..151966	-	1428	WP_003083784.1	GABA permease	-
KRP1_RS00710	152135..153628	-	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10464.21 Da
• Isoelectric Point: 10.0014

>T143508 WP_023114790.1 NZ_CP046069:c148422-148141 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDKVEITP

Nucleotide

• Length: 282 bp

>T143508 NZ_CP061170:c945138-944716 [Microbacterium sp. HY82]
GTGAAACTTCTGGATGTCGGCGTGTGGCTCGCGGCCGCCTGGGGCCGCCATATCGCACATCCAACCGTGCAGTCGTGGTT
TGATCAGCAGGACTCCGAACTCGTCTTCTGTCGAGTCACCGAGATGGGCTTTCTCCGATTGCTGTCGAATCCGAGCATCA
TGCGCGAGGACACCCTTACGCGAGCCGACAGCTGGTCAGTCCTCGATCGCCTTCGCGCTGACGAACGAGTGATACACCTC
GAGGAACCTACGAACCTCGAATCTGTATGGCGGACCCTTTCCGCCCGGGGCGACACAAGCCACAAGCTGTGGACGGACGA
CTACCTGGCCGCATTCGCTCAGGCTCGCGGCCTCTCAGTTGTGACCCTTGACCGCGCATTTGCCGGGCGCCATCAGTCCC
TCGAGGTCGAGCTGCTCAGTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT143508 WP_003083775.1 NZ_CP046069:c148646-148419 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT143508 NZ_CP061170:c945380-945135 [Microbacterium sp. HY82]
ATGCGCACAACGGTTGATCTCCCCGATGATCTGCTTCGCGCTCTCAAGGTGAGAGCGGCACAGCGAGGCGAGACGCTCAA
GGTTGTGCTGACGCGCGCGATCTCCCGCGAAATCGCTGGCAGCACGAACACACATACGCGAGTGACTCTGCCGCTTGTCG
CCGCGGGGGCGACACCAACGGTGAACGTCACATCGGACGATATCGCAGCGGCCCTGGCATCTGACGACGAACAGTACGCC
AAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9