Detailed information of TA system TA143506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 310724..311252
• Replicon: plasmid pTHAF191d_c
• Accession: NZ_CP046067
• Organism: Vibrio sp. THAF191d

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GGC04_RS26150
• Protein ID: WP_152472625.1
• Coordinates: 310724..311014 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Y3YX34
• Locus tag: GGC04_RS26155
• Protein ID: WP_006958739.1
• Coordinates: 311004..311252 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GGC04_RS26115	306233..306976	+	744	WP_152472629.1	transporter substrate-binding domain-containing protein	-
GGC04_RS26120	307427..307882	-	456	WP_152472628.1	DUF2079 domain-containing protein	-
GGC04_RS26125	307879..309045	-	1167	WP_152472906.1	hypothetical protein	-
GGC04_RS26130	309335..309448	+	114	WP_152472627.1	DUF3265 domain-containing protein	-
GGC04_RS26135	309504..309803	-	300	WP_043011872.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GGC04_RS26140	309811..310053	-	243	WP_152472626.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GGC04_RS26145	310329..310565	+	237	WP_021458677.1	hypothetical protein	-
GGC04_RS26150	310724..311014	-	291	WP_152472625.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GGC04_RS26155	311004..311252	-	249	WP_006958739.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GGC04_RS26160	311309..311437	+	129	WP_144382900.1	DUF3265 domain-containing protein	-
GGC04_RS26165	311583..312173	+	591	WP_040122585.1	Crp/Fnr family transcriptional regulator	-
GGC04_RS26170	312235..312681	+	447	WP_152472624.1	isoprenylcysteine carboxylmethyltransferase family protein	-
GGC04_RS26175	312803..313030	+	228	Protein_303	isocitrate lyase/phosphoenolpyruvate mutase family protein	-
GGC04_RS26180	313432..313911	-	480	WP_152472623.1	hypothetical protein	-
GGC04_RS26185	314692..315027	+	336	WP_064487238.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	htpB	1..396761	396761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.22 Da
• Isoelectric Point: 10.5339

>T143506 WP_152472625.1 NZ_CP046067:c311014-310724 [Vibrio sp. THAF191d]
MTYKLDFKKSALKEWKKLGATLQQQFKKKLIERLDNPHVLASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMNRLDD

Nucleotide

• Length: 291 bp

>T143506 NZ_CP061170:c904097-903837 [Microbacterium sp. HY82]
ATGAGCCGCGCGCTCGCGTTCGACAAGAACGGTTGGGAAGACTACGTCTATTGGCAAACCCAAGACCGCAAGACACTCAA
ACGGATCAACACGCTCATCGCAGACGTGCTCCGCGACCCATTCACCGGGATCGGAAAACCGGAACCACTCAAGCACATCC
TCAGCGGCGCCTGGTCGCGGCGCATCGACGAAACGAACCGACTCGTCTACTACGTCACCGACGACCACATTGTGATCCTC
CAAGCACGCGATCACTATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9030.29 Da
• Isoelectric Point: 3.9610

>AT143506 WP_006958739.1 NZ_CP046067:c311252-311004 [Vibrio sp. THAF191d]
MTTRILADVAASITELKANPMKVATSANGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT143506 NZ_CP061170:c904345-904094 [Microbacterium sp. HY82]
ATGCCCGCAATCACAGCAACTGAAGCACGCAAGAGCCTGTTCGGACTCATCCAGCGCGTCAACGATGACCACACTGCGGT
CGAGGTTGTTTCCAAGCACGGCAACGCAGTTATCCTCTCGAAAGACGACTACGACGCAATCACCGAGACCGCTTACTTGC
TGCGCAACTCCGCAAACGCTGAGCGTCTACTCGACGCGATCGAGCGCGCTCGACGCGGCGAGTTTGAACAGCACGATCTT
CTCGAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7Y3YX34