Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 309504..310053 | Replicon | plasmid pTHAF191d_c |
| Accession | NZ_CP046067 | ||
| Organism | Vibrio sp. THAF191d | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A2A2MR35 |
| Locus tag | GGC04_RS26135 | Protein ID | WP_043011872.1 |
| Coordinates | 309504..309803 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | GGC04_RS26140 | Protein ID | WP_152472626.1 |
| Coordinates | 309811..310053 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GGC04_RS26110 | 305180..306064 | + | 885 | WP_152472630.1 | LysR family transcriptional regulator | - |
| GGC04_RS26115 | 306233..306976 | + | 744 | WP_152472629.1 | transporter substrate-binding domain-containing protein | - |
| GGC04_RS26120 | 307427..307882 | - | 456 | WP_152472628.1 | DUF2079 domain-containing protein | - |
| GGC04_RS26125 | 307879..309045 | - | 1167 | WP_152472906.1 | hypothetical protein | - |
| GGC04_RS26130 | 309335..309448 | + | 114 | WP_152472627.1 | DUF3265 domain-containing protein | - |
| GGC04_RS26135 | 309504..309803 | - | 300 | WP_043011872.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GGC04_RS26140 | 309811..310053 | - | 243 | WP_152472626.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GGC04_RS26145 | 310329..310565 | + | 237 | WP_021458677.1 | hypothetical protein | - |
| GGC04_RS26150 | 310724..311014 | - | 291 | WP_152472625.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GGC04_RS26155 | 311004..311252 | - | 249 | WP_006958739.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GGC04_RS26160 | 311309..311437 | + | 129 | WP_144382900.1 | DUF3265 domain-containing protein | - |
| GGC04_RS26165 | 311583..312173 | + | 591 | WP_040122585.1 | Crp/Fnr family transcriptional regulator | - |
| GGC04_RS26170 | 312235..312681 | + | 447 | WP_152472624.1 | isoprenylcysteine carboxylmethyltransferase family protein | - |
| GGC04_RS26175 | 312803..313030 | + | 228 | Protein_303 | isocitrate lyase/phosphoenolpyruvate mutase family protein | - |
| GGC04_RS26180 | 313432..313911 | - | 480 | WP_152472623.1 | hypothetical protein | - |
| GGC04_RS26185 | 314692..315027 | + | 336 | WP_064487238.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | htpB | 1..396761 | 396761 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11439.05 Da Isoelectric Point: 9.3232
>T143505 WP_043011872.1 NZ_CP046067:c309803-309504 [Vibrio sp. THAF191d]
MQKNKYKLSNLAQSHLHKIKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK
MQKNKYKLSNLAQSHLHKIKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDG
FILVVAVLGQSQLPQNHLK
Download Length: 300 bp
>T143505 NZ_CP061169:c822700-822272 [Microbacterium sp. HY60]
ATGAAGCTGCTGGATGTCGGCGTGTGGCTCGCTGCCACTTGGGGCCGCCACGTCGCACATCCATCCGTACGAACGTGGTT
CGATCAGCAAGACTCCGAACTCGCCTTTTGTCGAGTCACCGAGATGGGCCTTCTCCGTTTGCTGTCGAATCCGAGCATCA
TGCGCGAGGACGCCCTCACGCGGGGCGCCACCTGGTCCGTCCTCGATCGTCTACGAGCTGATGACCGAGTGATACACCTT
GAGGAACCTACGAACCTCGAATCCGTGTGGAGGACGCTATCCGCACGGGACGACACAAGCCACAAACTGTGGACAGACGA
CTACCTGGCAGCATTTGCTCAGGCTCGCGGCCTCTCAGTTGTAACCCTTGACCGGGCATTTGCCCAACGTCATCAGTCCG
TAGAGGTCGAGCTTCTCGTCCGACGGTAG
ATGAAGCTGCTGGATGTCGGCGTGTGGCTCGCTGCCACTTGGGGCCGCCACGTCGCACATCCATCCGTACGAACGTGGTT
CGATCAGCAAGACTCCGAACTCGCCTTTTGTCGAGTCACCGAGATGGGCCTTCTCCGTTTGCTGTCGAATCCGAGCATCA
TGCGCGAGGACGCCCTCACGCGGGGCGCCACCTGGTCCGTCCTCGATCGTCTACGAGCTGATGACCGAGTGATACACCTT
GAGGAACCTACGAACCTCGAATCCGTGTGGAGGACGCTATCCGCACGGGACGACACAAGCCACAAACTGTGGACAGACGA
CTACCTGGCAGCATTTGCTCAGGCTCGCGGCCTCTCAGTTGTAACCCTTGACCGGGCATTTGCCCAACGTCATCAGTCCG
TAGAGGTCGAGCTTCTCGTCCGACGGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9073.29 Da Isoelectric Point: 5.1051
>AT143505 WP_152472626.1 NZ_CP046067:c310053-309811 [Vibrio sp. THAF191d]
MYTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL
MYTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL
Download Length: 243 bp
>AT143505 NZ_CP061169:c822942-822697 [Microbacterium sp. HY60]
ATGCGCACAACGATTGATCTCCCCGATGATCTGCTTCGCGCTCTCAAAGTGAGAGCCGCACAGCGAGGCGAGACACTCAA
GGTTGTGCTGATGCGTGCAGTTTCCCGCGAAGTCGCTGGCAACACGAACGCACATACGCGGGTCTCTCTGCCGCTTATCG
CCGCAGGGGCAGAGCCAACAGTTGATGTCACACCGGACGATATCGCCACGGCCCTGGCGTCCGATGACGAACAGTACGCT
CGATGA
ATGCGCACAACGATTGATCTCCCCGATGATCTGCTTCGCGCTCTCAAAGTGAGAGCCGCACAGCGAGGCGAGACACTCAA
GGTTGTGCTGATGCGTGCAGTTTCCCGCGAAGTCGCTGGCAACACGAACGCACATACGCGGGTCTCTCTGCCGCTTATCG
CCGCAGGGGCAGAGCCAACAGTTGATGTCACACCGGACGATATCGCCACGGCCCTGGCGTCCGATGACGAACAGTACGCT
CGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|