Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5045180..5046438 Replicon chromosome
Accession NZ_CP046061
Organism Pseudomonas aeruginosa strain 1811-13R031

Toxin (Protein)


Gene name - Uniprot ID A0A241XTS2
Locus tag GJV01_RS23705 Protein ID WP_023464370.1
Coordinates 5045180..5045935 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A241XST8
Locus tag GJV01_RS23710 Protein ID WP_023464369.1
Coordinates 5046070..5046438 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV01_RS23695 5040351..5042894 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
GJV01_RS23700 5043049..5044410 - 1362 WP_003081943.1 DNA recombination protein RmuC -
GJV01_RS23705 5045180..5045935 - 756 WP_023464370.1 RES family NAD+ phosphorylase Toxin
GJV01_RS23710 5046070..5046438 - 369 WP_023464369.1 DUF2384 domain-containing protein Antitoxin
GJV01_RS23715 5046511..5047797 - 1287 WP_023464368.1 FAD-binding oxidoreductase -
GJV01_RS23720 5047853..5049442 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
GJV01_RS23725 5049520..5049996 + 477 WP_019725934.1 hypothetical protein -
GJV01_RS35025 5049999..5050274 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28226.37 Da        Isoelectric Point: 7.6839

>T143500 WP_023464370.1 NZ_CP046061:c5045935-5045180 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAECAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRASQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T143500 NZ_CP061134:1627187-1627522 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13395.68 Da        Isoelectric Point: 9.9874

>AT143500 WP_023464369.1 NZ_CP046061:c5046438-5046070 [Pseudomonas aeruginosa]
MSVLIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT143500 NZ_CP061134:1626910-1627197 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XTS2

Antitoxin

Source ID Structure
AlphaFold DB A0A241XST8

References