143497

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2563883..2564925 Replicon chromosome
Accession NZ_CP046061
Organism Pseudomonas aeruginosa strain 1811-13R031

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag GJV01_RS12130 Protein ID WP_003153636.1
Coordinates 2564350..2564925 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag GJV01_RS12125 Protein ID WP_003050245.1
Coordinates 2563883..2564353 (+) Length 157 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV01_RS12090 2559268..2560686 - 1419 WP_047219621.1 TIGR03752 family integrating conjugative element protein -
GJV01_RS12095 2560676..2561593 - 918 WP_047219622.1 TIGR03749 family integrating conjugative element protein -
GJV01_RS12100 2561590..2562282 - 693 WP_004350603.1 TIGR03746 family integrating conjugative element protein -
GJV01_RS12105 2562279..2562677 - 399 WP_003153632.1 TIGR03750 family conjugal transfer protein -
GJV01_RS12110 2562690..2563049 - 360 WP_003153634.1 TIGR03745 family integrating conjugative element membrane protein -
GJV01_RS12115 2563066..2563299 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
GJV01_RS12120 2563296..2563679 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
GJV01_RS12125 2563883..2564353 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
GJV01_RS12130 2564350..2564925 + 576 WP_003153636.1 PIN domain-containing protein Toxin
GJV01_RS12135 2564943..2565857 + 915 WP_003050256.1 AAA family ATPase -
GJV01_RS12140 2565854..2566324 + 471 WP_003153638.1 hypothetical protein -
GJV01_RS12145 2566321..2566821 + 501 WP_003090159.1 hypothetical protein -
GJV01_RS12150 2566821..2567723 + 903 WP_003153640.1 nucleotidyltransferase domain-containing protein -
GJV01_RS12155 2567762..2568487 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2503602..2614452 110850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-114)

Antitoxin

(85-133)


Sequences


Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T143497 WP_003153636.1 NZ_CP046061:2564350-2564925 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T143497 NZ_CP061131:1663688-1664023 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT143497 WP_003050245.1 NZ_CP046061:2563883-2564353 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT143497 NZ_CP061131:1663411-1663698 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References