Detailed information of TA system TA143495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 1760645..1762340
• Replicon: chromosome
• Accession: NZ_CP046061
• Organism: Pseudomonas aeruginosa strain 1811-13R031

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A1C7C456
• Locus tag: GJV01_RS08280
• Protein ID: WP_022579703.1
• Coordinates: 1760645..1761514 (+)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1C7C9F9
• Locus tag: GJV01_RS08285
• Protein ID: WP_017001846.1
• Coordinates: 1761507..1762340 (+)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJV01_RS08255	1756654..1757505	+	852	WP_003130104.1	ABC transporter ATP-binding protein	-
GJV01_RS08260	1757545..1758552	+	1008	WP_023108660.1	ABC transporter substrate-binding protein	-
GJV01_RS08265	1758549..1759325	+	777	WP_003112898.1	ABC transporter permease	-
GJV01_RS08270	1759331..1760092	+	762	WP_023106074.1	SDR family oxidoreductase	-
GJV01_RS08275	1760106..1760636	+	531	WP_003112900.1	cupin domain-containing protein	-
GJV01_RS08280	1760645..1761514	+	870	WP_022579703.1	alpha/beta hydrolase	Toxin
GJV01_RS08285	1761507..1762340	+	834	WP_017001846.1	IclR family transcriptional regulator	Antitoxin
GJV01_RS08290	1762327..1763124	+	798	WP_003112903.1	SDR family oxidoreductase	-
GJV01_RS08295	1763117..1764799	+	1683	WP_031692523.1	thiamine pyrophosphate-binding protein	-
GJV01_RS08300	1764810..1765613	+	804	WP_003112905.1	aspartate dehydrogenase	-
GJV01_RS08305	1765625..1767109	+	1485	WP_017001843.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (41-272)

Antitoxin

• Transcription regulator IclR, N-terminal (16-66)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 30389.65 Da
• Isoelectric Point: 6.8139

>T143495 WP_022579703.1 NZ_CP046061:1760645-1761514 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Nucleotide

• Length: 870 bp

>T143495 NZ_CP061128:7053-7307 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30867.22 Da
• Isoelectric Point: 5.7725

>AT143495 WP_017001846.1 NZ_CP046061:1761507-1762340 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRSHETV

Nucleotide

• Length: 834 bp

>AT143495 NZ_CP061128:7304-7546 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

Structures

Toxin

• AlphaFold DB: A0A1C7C456

Antitoxin

• AlphaFold DB: A0A1C7C9F9