Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2725395..2725948 Replicon chromosome
Accession NZ_CP046060
Organism Pseudomonas aeruginosa strain 1811-18R001

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag GJV02_RS13100 Protein ID WP_010953434.1
Coordinates 2725655..2725948 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag GJV02_RS13095 Protein ID WP_010953433.1
Coordinates 2725395..2725667 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV02_RS13065 2720967..2721326 - 360 Protein_2582 DNA repair protein RadC -
GJV02_RS13070 2721298..2722248 - 951 WP_031299400.1 hypothetical protein -
GJV02_RS13075 2722341..2723345 - 1005 WP_010953429.1 YqaJ viral recombinase family protein -
GJV02_RS13080 2723425..2724393 - 969 WP_031299399.1 DUF932 domain-containing protein -
GJV02_RS13085 2724491..2724763 - 273 WP_031299398.1 hypothetical protein -
GJV02_RS13090 2725025..2725270 + 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GJV02_RS13095 2725395..2725667 + 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
GJV02_RS13100 2725655..2725948 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJV02_RS13105 2725942..2727240 - 1299 WP_154355144.1 site-specific integrase -
GJV02_RS13110 2727237..2728783 - 1547 Protein_2591 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2722341..2748660 26319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T143489 WP_010953434.1 NZ_CP046060:2725655-2725948 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T143489 NZ_CP061109:90471-90887 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT143489 WP_010953433.1 NZ_CP046060:2725395-2725667 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT143489 NZ_CP061109:90244-90474 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References